Effect of Carbamazepine on Substance P Content in the Rat Brain

  • H. Mitsushio
  • M. Takashima
  • M. Toru
Conference paper


Carbamazepine (CBZ) is known to be a potent anti-epileptic drug. Like lithium it has been reported to prevent the oscillation of manic-depressive psychosis [1][2]. Although the mechanisms of action of both drugs in the brain are not well known, it is possible that they affect some neurotransmitters or neuromodulators in a similar manner. It has been reported that chronic lithium administration increased the substance P (SP) content in the dopamine related brain areas, and co-administration of haloperidol (HAL) prevented this effect [3][4]. We have studied the effect of CBZ, HAL and trihexyphenidyl (TR) alone or in combination on SP content as well as dopamine (DA), serotonin (5HT), glutamate and γ-aminobutyric acid (GABA) in the rat brain.


Substantia Nigra Methionine Sulfoxide Chronic Lithium Hydroxyindolacetic Acid Phosphate Buffer Acetonitrile 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • H. Mitsushio
    • 1
  • M. Takashima
    • 1
  • M. Toru
    • 2
  1. 1.Division of PsychobiologyNational Center for Nervous, Mental and Muscular DisordersTokyoJapan
  2. 2.Department of PsychiatryShinsu University School of MedicineMatsumotoJapan

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