Effect of Carbamazepine on Substance P Content in the Rat Brain
Carbamazepine (CBZ) is known to be a potent anti-epileptic drug. Like lithium it has been reported to prevent the oscillation of manic-depressive psychosis . Although the mechanisms of action of both drugs in the brain are not well known, it is possible that they affect some neurotransmitters or neuromodulators in a similar manner. It has been reported that chronic lithium administration increased the substance P (SP) content in the dopamine related brain areas, and co-administration of haloperidol (HAL) prevented this effect . We have studied the effect of CBZ, HAL and trihexyphenidyl (TR) alone or in combination on SP content as well as dopamine (DA), serotonin (5HT), glutamate and γ-aminobutyric acid (GABA) in the rat brain.
KeywordsHPLC Lithium Dopamine Acetonitrile Glycol
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