Aldose Reductase and Complications of the Eye

  • Margo Panush Cohen


The paradigm for the participation of the polyol pathway in the pathogenesis of a complication of diabetes is the ocular lens, the first tissue in which an association between excess sorbitol formation and a pathologic change was described. The discovery by Von Heyningen that the lenses of rats in which cataracts had been induced by diabetes, or by galactose or xylose feeding, contained increased amounts of the respective sugar alcohols sorbitol, galactitol, and xylitol provided an explanation for certain histopathologic features that had been observed in developing cataracts.1,2 These features consisted of the early appearance of hydropic lens fibers, followed by rupture of the swollen fibers, liquefaction, and replacement by vacuoles or interfibrillar clefts.


Aldose Reductase Human Lens Mural Cell Polyol Pathway Aldose Reductase Inhibitor 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • Margo Panush Cohen
    • 1
  1. 1.Division of Endocrinology and MetabolismUniversity of Medicine and Dentistry of New JerseyNewarkUSA

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