Selenium pp 205-212 | Cite as

The Distribution of Selenium in Human Blood Samples of Israeli Population—Comparison between Normal and Breast Cancer Cases

  • S. Chaitchik
  • C. Shenberg
  • Y. Nir-El
  • M. Mantel

Abstract

A preliminary study was carried out in order to compare the selenium concentration in breast cancer patients and healthy subjects (controls) in Israel. Blood serum samples were obtained from 32 breast cancer patients and 36 controls and were analyzed for selenium by the XRF method. A weighted mean of 0.076 ± 0.014 ppm Se in the blood serum of breast cancer patients, as compared to 0.119 ± 0.023 ppm Se for controls, was obtained. These results indicate that the concentration of selenium in breast cancer patients is significantly lower than in controls. The relationship between selenium concentration and malignancy stage shows an inverse dependence, i.e., the concentration decreases with stage number.

Keywords

Polyethylene Selenium 

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References

  1. 1.
    G. F. Combs Jr., C. H. Liu, Z. H. Lu, and Q. Su, J. Nutr. 114, 964–976, (1984).PubMedGoogle Scholar
  2. 2.
    M. L. Scott J. Nutr. 103, 803–810, (1973).PubMedGoogle Scholar
  3. 3.
    G. N. Schrauzer et al., Bioinorg. Chem. 7, 23–34, (1977).PubMedCrossRefGoogle Scholar
  4. 4.
    G. N. Schrauzer, in Vitamins, Nutrition and Cancer, Prasad, ed., Karger, Basel, 240–250, (1984).Google Scholar
  5. 5.
    A. C. Griffin and M. M. Jacobs, Cancer Lett. 3, 177–181, (1977).PubMedCrossRefGoogle Scholar
  6. 6.
    M. M. Jacobs, B. Jansson, and A. C. Griffin, Cancer Lett. 2, 133–138, (1977).PubMedCrossRefGoogle Scholar
  7. 7.
    U. M. Cowgill, Biol. T. Eiern. Res. 5, 345–361, (1983).CrossRefGoogle Scholar
  8. 8.
    Ya-Sun Chu, Qiu-Yan Liu, Chong Hou, and Shu-Yu Yu, Biol. T. Elem. Res. 6, 133–137, (1984).CrossRefGoogle Scholar
  9. 9.
    H. Sundstrom, E. Yrjanheikki, and A. Kauppila, Carcinogenesis 5, 731–734, (1984).PubMedCrossRefGoogle Scholar
  10. 10.
    L. N. Vernie, Biochim. Biophys. Acta 738, 203–217, (1984).PubMedGoogle Scholar
  11. 11.
    G. T. Salonen, G. Alfthan, J. K. Huttunen, and P. Puska, Am. J. Apidemiol. 120, 342–347, (1984).Google Scholar
  12. 12.
    H. Sundstrom, E. Yrjanheikki, and A. Kauppila, Int. J. Gynaecol. Obstet. 22, 35–40, (1984).PubMedCrossRefGoogle Scholar
  13. 13.
    L. Nelson, Dis. Colon Rectum 27, 459–461, (1984).PubMedCrossRefGoogle Scholar
  14. 14.
    P. Calautti, G. Moshini, B. M. Stievano, L. Tomio, F. Calzavara, and G. Perona, Scand. J. Haematol. 24, 63–64, (1980).PubMedCrossRefGoogle Scholar
  15. 15.
    TNM-Classification of malignant tumors. UICC (International Union Against Cancer). Third enlarged and revised ed. (1982).Google Scholar
  16. 16.
    N. Ellis, B. Lloyd, R. S. Lloyd, and E. B. Clayton, J. Clin. Pathol. 37, 200–206, (1984).PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1988

Authors and Affiliations

  • S. Chaitchik
    • 1
  • C. Shenberg
    • 2
  • Y. Nir-El
    • 2
  • M. Mantel
    • 2
  1. 1.Elias Sourasky Medical CenterTel-AvivIsrael
  2. 2.Soreq Nuclear Research CenterYavneIsrael

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