Abstract
[3H]Tryptamine labels high affinity (2–3 nM) binding sites in rat brain and other tissues with a unique pharmacological profile (Cascio and Kellar, 1983). Other than tryptamine itself, compounds exhibiting high affinity for this site include β-carbolines (including harmaline and related drugs) and phenethylamines (Cascio and Kellar, 1982, 1983; Bruning and Rommelspacher, 1984; Wood et al, 1984) and kynuramines and related compounds (Charlton et al., 1985). 5-Hydroxytryptamine (serotonin) has only modest affinity for these sites. In vitro autoradiography studies revealed that [3H]tryptamine binding sites are widely distributed throughout the brain, with highest levels in forebrain and limbic areas, including cortex, caudate putamen, hippocampus, olfactory tubercle, nucleus accumbens, amygdala and interpeduncular nucleus (Perry, 1986; Altar et al., 1986; Kaulen et al., 1986; McCormack et al., 1986). Autoradiography also revealed very dense binding of [3H]tryptamine in the choroid plexus.
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Perry, D.C., Grimm, L.J., Martino-Barrows, A.M., Jones, M.L., Kellar, K.J. (1988). Comparison of the Binding of [3H] Tryptamine in Rat Brain with that of Two Ligands for Monoamine Oxidase, [3H]MPTP and [3H]Pargyline. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_8
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_8
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