Monoamines as Targets for Insecticide Discovery
Although many chemical insecticides are available for crop protection, grain storage, homeowner and public health uses, the majority of these materials fall into a few small classes of chemistry when classified by modes of action. When these insecticide classes are examined, it becomes clear that the majority of insecticides in use today exert their toxic action on the insect nervous system.
KeywordsDopamine Nicotine Serotonin Catecholamine Chitin
Unable to display preview. Download preview PDF.
- Eldefrawi A.T. (1985). Acetylcholinesterases and anticholinesterases, In, Comprehensive Insect Physiology Biochemistry and Pharmacology Vol. 12 (Kerkut G.A. and Gilbert L.I., eds) pp 115–130 Pergamon Press, U.K.Google Scholar
- Eldefrawi M.E. (1985). Nicotine. In, Comprehensive Insect Physiology Biochemistry and Pharmacology Vol. 12 (Kerkut G.A. and Gilbert L.I., eds) pp 263–272 Pergamon Press, U.K.Google Scholar
- Evans P.D. (1985). Biogenic amines and second messenger systems in insects. In, Approaches to New Leads for Insecticides (von Keyserlingk H.C., Jager A. and von Szczepanski C.H., eds) pp 117–131 Springer-Verlag, FRG.Google Scholar
- Hollingworth R.M. and Johnstone E.M. (1985). Pharmacology and toxicology of octopamine receptors in insects. In, Pesticide Chemistry Human Welfare and the Environment Vol. 1 (Miyamoto J. and Kearney P.C., eds) pp 187–192 Pergamon Press, U.K.Google Scholar
- Jennings K.R., Brown D.G., Wright Jr. D.P. and Chalmers A.E. (1987). Methyllycaconitine — a potent natural insecticide active on cholinergic receptors. In, The Search for Novel Pest Control Agents-Receptors for GABA, Octopamine and Other Neuroreceptors. ACS Symposium Series IN PRESS.Google Scholar
- Mitsui T. (1985). Chitin synthesis inhibitors: benzoyl-arylurea insecticides. Jap. Pest. Inform. 47 3–7.Google Scholar
- Nathanson J.A. (1985). Phenyliminoimidazolidines: characterization of a class of potent agonists of octopamine-sensitive adenylate cyclase and their use in understanding the pharmacology of octopamine receptors. Mol. Pharmacology 28, 254–268.Google Scholar
- Nathanson J.A. and Hunnicutt E.J. (1981). N-Demethyl-chlordimeform: A potent partial agonist of octopamine-sensitive adenylate cyclase. Mol. Pharmacology 20, 68–75.Google Scholar
- Omar D., Murdock L.L. and Hollingworth R.M. (1982). Actions of pharmacological agents on 5-hydroxytryptamine and dopamine in the cockroach nervous system (Periplaneta americana L.). Comp. Biochem. Physiol. 73C, 423–429.Google Scholar
- Timmermans P.B.M.W.M., de Jonge A., van Meel J.C.A., P. Slothorst-Grisdijk, Lam E. and Van Zwieten P.A. (1981). Characterization of α-adrenoceptor populations. Quantitative relationships between cardiovascular effects initiated at central and peripheral α-adrenoceptors. J. Med. Chem. 24, 5 502–507.PubMedCrossRefGoogle Scholar
- Wollweber H., Hiltmann R. and Stendel W. (1971). 2-(arylimino)oxazolidines. Ger. Offen. 1,963,192.Google Scholar
- Wright T.R.F. (1987). The genetics of biogenic amine metabolism, sclerotization and melanization in Drosophila melanogaster. Advances in Genetics 25 (in press)Google Scholar