Abstract
Octopamine is a biogenic amine that was first discovered in the posterior salivary glands of the octopus (Erspamer and Boretti, 1951). Since that time it has been shown to be a ubiquitous constituent of all nervous systems examined, all the way from nematodes and earthworms up to vertebrates, including humans (see Evans, 1980; 1985a). The functional role of octopamine in the vertebrate nervous system, however, is at present enigmatic (Harmar, 1980; Talamo, 1980; Robertson, 1981). Octopamine occurs in three different structural isomeric forms, para-, meta- and ortho-octopamines, all of which have been shown to occur naturally in vertebrates (Williams, Couch and Midgley, 1984). The occurrence of p-and m-octopamine in the sympathetic nervous system (Ibrahim, Couch, Williams, Fregley and Midgley, 1985) and brain (Danielson, Boulton and Robertson, 1977; David and Delacour, 1980) has led to the suggestion that they may function as co-transmitters or modulators of noradrenaline action.
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Evans, P.D. (1988). Octopamine Receptors on Locust Skeletal Muscle. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_2
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_2
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