An Interaction between β-Phenylethylamine and Noradrenaline: An Iontophoretic Study in the Rat Cerebral Cortex
The trace amines are a group of endogenous aromatic amines found in low concentrations in the nervous systems of many invertebrate and vertebrate species. They are a diverse group of compounds and it seems likely that they have diverse functions. It has been postulated that trace amines may act as neuromodulators (Boulton, 1976, 1980), false transmitters (Baldessarini, 1974), co-transmitters (Axelrod and Saavedra, 1977), or that they may be neurotransmitters in their own right (Jones, 1982b, Stoof et al. 1976).
KeywordsCortical Neurone Locus Coeruleus Biphasic Response Iontophoretic Application Trace Amine
Unable to display preview. Download preview PDF.
- Baldessarini, J., (1974) Release of catecholamines. In Handbook of Psychopharmacology. Vol. 3 (I.I.I. Verson, S.D. Iverson and S.H. Snyder, Eds), p37–114, Plenum, New York and London.Google Scholar
- Boulton, A.A., (1976) Cerebral aryl alkyl aminergic mechanisms. In Trace Amines and the Brain (E. Usdin and M. Sandler, Eds), p22–39, Marcel Dekker, New York.Google Scholar
- Boulton, A.A., (1980) The trace amines: Neurohumours, Behav. Brain Sci., 7, 418.Google Scholar
- Horn, A.D. and Snyder, S.H., (1973) Steric requirements for catecholamine uptake by rat brain synaptosomes: studies with rigid analogues of amphetamine, J. Pharmacol, Exp. Ther., 180, 523–530.Google Scholar
- Phillips, S.R., Rozdilsky, B. and Boulton, A.A., (1978) Evidence for the presence of m-tyramine, p-tyramine, tryptamine and phenyethylamine in the rat brain and several areas of the human brain, Biol. Psychiat., 13, 51–57.Google Scholar
- Stoof, J.C., Liem, A.L. and Mulder, A.H., (1976) Release and receptor stimulating properties of p-tyramine in rat brain, Arch. Int. Pharmacodynam., 220, 62–71.Google Scholar
- Wu, P.H. and Boulton, A.A., (1975) Metabolism, distribution and disappearance of injected β-phenylethylamine in the rat, Can. J. Biochem., 53, 42–50.Google Scholar