Abstract
The mammalian cerebral cortex receives catecholamine-containing afférents, and at least two such systems have been very well documented: [1 the noradrenergic (NA) projections originating from the Locus coeruleus or A6 region, and 2] the cortical dopaminergic (DA) fibers arising from the Substantia nigra and the adjacent ventral tegmental area, or A9 and A10 regions (Dahlström and Fuxe, 1964; Ungerstedt, 1971). The presence of significant numbers of catecholamine-containing axonal varicosities, presumed to be the terminals and release sites, was first demonstrated by fluorescence histochemistry. Based on these anatomical findings it was soon implied that they could be acting as conventional neurotransmitters in cerebral cortex. This was supported by the in vivo release studies of cortical DA and NA (Reader et al., 1976), as well as by numerous electrophysiological investigations (Bunney and Aghajanian, 1976; Krnjević and Phillis, 1963; Reader, 1978, 1980; Reader et al., 1979a; Stone, 1973) showing effects of these CA upon cortical neurons.
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Reader, T.A., Gottberg, E., Kolta, A., Brière, R., Diop, L., Grondin, L. (1988). Dopamine in the Neocortex: A Classical Monoamine Neurotransmitter as a Trace Amine. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_15
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_15
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