Abstract
Major problems in the analysis of trace amine function have been (i) the low basal levels of these compounds, hindering their analysis as dependent variables; and (ii) their rapid and extensive oxidative deamination by monoamine oxidase (MAO), necessitating the use of high doses. With respect to the latter problem both the rather massive pharmacological effects of these amines and their problematic pharmaco-kinetic/dynamic profiles have hindered their manipulation as independent variables. Few data are available describing attempts to systematically assess selective alterations of trace amines at relatively low concentrations in the central nervous system (CNS). The present paper describes some aspects of current approaches to these problems in the context of behavior analysis, particularly in relation to dopamine (DA) function in the CNS.
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Greenshaw, A.J. (1988). Neurobehavioral Aspects of Trace Amine Functions: Affective and Motoric Responses. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_13
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_13
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