Abstract
Rats implanted with a permanently indwelling intrathecal (IT) cannula and naive mice were injected IT with tryptamine (TA) or tryptophan to determine their effects on nociception using various nociceptive tests. Tryptamine IT in rats has been found to decrease the nociceptive threshold measured using the tail flick assay. This effect is also elicited by tryptophan and is potentiated by coadministration or pretreatment with methysergide. In mice, TA IT enhanced the number of writhes evoked in the writhing assay but did not alter the latency of response in the hot plate assay. Tryptophan IT in mice also enhanced the number of writhes, but only after pretreatment with methysergide.
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References
Christian, S.T. and Harrison, R.E. (1981) Stress elevation of peripheral tryptamine tissue content. Neuroscience 7, 869.
D’Amour, F.E. and Smith, D.L. (1941) A Method for determining loss of pain sensation. J. Pharm, exp. Ther. 72, 74–79.
Harrison, R.E.W. and Christian, S.T. (1983) Individual housing stress elevates brain and adrenal tryptamine content, Neurobiology of Trace Amines (Boulton, A.A., Baker, G.B., Dewhurst, W.G., and Sandler, M., eds) pp. 249–255.
Hylden, J.L.K. and Wilcox, G.L. (1980) Intrathecal morphine in mice: a new technique, Eur. J. Pharmacol. 67, 313–316.
Larson, A.A. (1983) Hyperalgesia produced by the intrathecal administration of tryptamine to rats. Brain Res. 265, 109–117.
Larson, A.A. (1985) Distribution of CNS sites sensitive to tryptamine and serotonin in pain processing. In, Neuropsychopharmacology of the Trace Amines (Boulton, A.A., Maitre, L., Bieck, P.R. and Reiderer, P., eds) pp. 241–248.
Larson, A.A., Brown, D.R., El-Atrash, S. and Walser, M.M. (1985) Pain-thresholds in adjuvant-induced inflammation: A Possible model of chronic pain in the mouse. Pharmacol. Biochem. Behav. 24: 49–53.
Messing, R.B. and Lytle, L.G. (1977) Serotonin-containing neurons: their possible role in pain and analgesia. Pain 4: 1–21.
Moir, A.T.B. and D. Eccleston (1968) The effect of precursor loading in the cerebral metabolism of 5-hydroxyindoles. J. Neurochem. 15, 1093–1108.
Pircio, A.W., Fedele, C.T., and Bierwagen, M.E. (1975) A New method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat. Eurp. J. Pharmacol. 31, 207–215.
Steel, R.G.D. and J.H. Torrie (1960) Principles and Procedures of Statistics, McGraw-Hill, New York.
Weil-Fugazza, J., Godefroy, F., Coudert, D. and Besson, J.M. (1980) Total and free serum tryptophan levels and brain 5-hydroxytryptamine metabolism in arthritic rats. Pain 9, 319–325.
Winer, B.J. (1971) Statistical Prinicples in Experimental Design, Second Edition, McGraw-Hill, New York.
Yaksh, T.L. (1978) Analgesic actions of intrathecal opiates in cat and primate. Brain Res. 153, 205–210.
Yaksh, T.L. and Rudy, T.A. (1976) Chronic catherization of the spinal subarachnoid space. Physiol. Behav. 17, 1031–1036.
Yaksh, T.L. and Wilson, P.R. (1979) Spinal serotonin terminal system mediates antinociception. J. Pharm, exp. Ther. 208, 446–453.
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© 1988 The Humana Press Inc.
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Larson, A.A. (1988). Tryptamine, Tryptophan and Nociception. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_12
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_12
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