Abstract
Helper T cells recognize antigen in association with class II MHC products (Ia molecules) on the surface of antigen-presenting cells (1, 2). Structural studies have demonstrated that the antigen receptor of both T and B cells is encoded by variable, diversity, joining and constant gene segments rearranged during ontogeny to generate approximately the same diversity of ligand binding sites (3). Unlike immunoglobulins, recognizing soluble, unprocessed protein antigens, the antigen receptor of T lymphocytes recognizes a bimolecular complex composed of class II MHC molecules and an antigen fragment derived from proteolytic digestion of the native molecule (4, 5). The simultaneous recognition by a single receptor of antigen associated to la molecules indicates that for effective T cell recognition antigen and la molecules must physically interact on the membrane of antigen-presenting cells (6).
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Adorini, L., Bove, C., Darsley, M., Appella, E., Doria, G. (1987). Mapping of Antigen Epitopes Interacting with Class II MHC Products and with the Antigen Receptor of T Lymphocytes. In: Chaiken, I., Chiancone, E., Fontana, A., Neri, P. (eds) Macromolecular Biorecognition. Experimental Biology and Medicine, vol 19. Humana Press. https://doi.org/10.1007/978-1-4612-4600-8_24
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DOI: https://doi.org/10.1007/978-1-4612-4600-8_24
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