Abstract
This chapter extends the discussion provided in Chapter 1 by providing an overview of the development of criteria for subclassification of alpha-adrenergic receptors into alpha-1 vs alpha-2 adrenergic receptor sybtypes and of more recent data suggesting the existence of subtypes of alpha-2 adrenergic receptors. A compendium of structure—activity data is then provided that ultimately permits a description of the structural requirements for the ligand-binding site of an alpha-2 adrenergic receptor.
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Ruffolo, R.R., DeMarinis, R.M., Wise, M., Hieble, J.P. (1988). Structure—Activity Relationships for alpha-2 Adrenergic Receptor Agonists and Antagonists. In: Limbird, L.E. (eds) The alpha-2 Adrenergic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4596-4_4
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