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Mechanisms for Inhibition of Adenylate Cyclase by alpha-2 Adrenergic Receptors

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Book cover The alpha-2 Adrenergic Receptors

Part of the book series: The Receptors ((REC))

Abstract

Regulation of cellular functions by hydrophilic transmitters, e.g., catecholamines, requires efficient mechanisms for signal transduction across the plasma membrane. Generally speaking, these mechanisms function by translating the primary message, i.e., presence or absence of a hormone or neurotransmitter at the outer surface of the plasma membrane, into one or more second messages inside the cell, e.g., changes in cytosolic concentrations of cyclic nucleotides or calcium ions, modulation of ion fluxes across the cell membrane, altered metabolism of phosphoinositides, or phosphorylation of cellular proteins by receptor-driven protein kinases.

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Authors
  1. Peter Gierschik
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  2. Karl H. Jakobs
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Editors and Affiliations

  1. Vanderbilt University, Nashville, Tennessee, USA

    Lee E. Limbird

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© 1988 The Humana Press Inc.

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Gierschik, P., Jakobs, K.H. (1988). Mechanisms for Inhibition of Adenylate Cyclase by alpha-2 Adrenergic Receptors. In: Limbird, L.E. (eds) The alpha-2 Adrenergic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4596-4_3

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  • DOI: https://doi.org/10.1007/978-1-4612-4596-4_3

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8942-5

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