Studies of Gene Expression During Granulocyte Maturation

  • Edward J. BenzJr.
  • Katherine A. High
  • Karen Lomax
  • Catherine Stolle
  • Thomas A. Rado
  • Jay W. Schneider
  • Robert W. Mercer
Part of the Experimental Biology and Medicine book series (EBAM, volume 17)


Hematopoiesis is the process by which a pluripotent stem cell gives rise to the formed elements (recognizable differentiated cells) of the blood. These include red cells, platelets, lymphocytes, and cells of the granulocyte monocyte series (neutrophils, eosinophils, basophils, and monocyte-macrophages). The cellular biology and biochemistry of hematopoiesis have been intensively studied because the hematopoietic system is of fundamental scientific and clinical importance. As a biological phenomenon, hematopoiesis represents the most striking and readily examined example of differentiation by a single parent stem cell along several alternate cellular pathways. At the clinical level, hematopoiesis represents the means by which the body is supplied with cells needed for oxygen transport, infection resistance, and hemostasis.


HL60 Cell Hypersensitive Site Chronic Granulocytic Leukemia Commit Stem Cell Stern Cell 
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Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Edward J. BenzJr.
    • 1
  • Katherine A. High
    • 1
  • Karen Lomax
    • 1
  • Catherine Stolle
    • 1
  • Thomas A. Rado
    • 1
  • Jay W. Schneider
    • 1
  • Robert W. Mercer
    • 1
  1. 1.Departments of Internal Medicine and Human GeneticsYale University School of MedicineNew HavenUSA

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