Abstract
The human leukemic population is an heterogeneous collection of cells arising from a malignant clone of undifferentiated progenitor cells analogous in some respects to the normal hemopoietic cells (1–3). These leukemic progenitors are capable both of self-renewal and differentiation that very often is highly abnormal. The differentiation level (most immature stem cell or intermediate progenitor cell) at which the leukemic transformation occurs has been defined in lymphocytic leukemia, where marker events involving progressive rearrangement of specific genes (immunoglobulin genes for B-ALL and and T cell receptor genes for T-ALL) leave irreversible footprints in the DNA (32,33). In the case of acute undifferentiated leukemias (AUL) or acute myelogenous leukemias (AML) gene rearrangements during progression of differentiation do not occur, or at least they have not been identified and the differentiation stage of the progenitor cells that are targets for the various types of AML is still largely undefined.
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Rovera, G., Lange, B. (1987). Proliferation and Differentiation of Human Leukemic Cells in Culture. In: Aarbakke, J., Chiang, P.K., Koeffler, H.P. (eds) Tumor Cell Differentiation. Experimental Biology and Medicine, vol 17. Humana Press. https://doi.org/10.1007/978-1-4612-4594-0_4
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DOI: https://doi.org/10.1007/978-1-4612-4594-0_4
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