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Tumor Promoter-Mediated Modulation of Cell Differentiation and Communication: The Phorbol Ester — Oncogene Connection

  • Chapter
Tumor Cell Differentiation

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 17))

Abstract

Proto-oncogenes, when expressed inappropriately or in altered form have the potential to cause cancer. Cancer is usually accompanied by a loss of cellular differentiation and by enhanced proliferation. As the normal function of proto-oncogenes appears to include control of cell differentiation and proliferation, aberrant function of these oncogenes is probably involved in the various molecular events that contribute to the development of malignancy.

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Authors and Affiliations

  1. International Agency for Research on Cancer, 150 cours A.Thomas, 69372, Lyon cedex 08, France

    Monica Hollstein & Hiroshi Yamasaki

Authors
  1. Monica Hollstein
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  2. Hiroshi Yamasaki
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Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsö, Tromsö, Norway

    Jarle Aarbakke

  2. Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC, USA

    Peter K. Chiang

  3. University of California, Los Angeles, California, USA

    H. Phillip Koeffler

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© 1987 The Humana Press Inc.

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Hollstein, M., Yamasaki, H. (1987). Tumor Promoter-Mediated Modulation of Cell Differentiation and Communication: The Phorbol Ester — Oncogene Connection. In: Aarbakke, J., Chiang, P.K., Koeffler, H.P. (eds) Tumor Cell Differentiation. Experimental Biology and Medicine, vol 17. Humana Press. https://doi.org/10.1007/978-1-4612-4594-0_24

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  • DOI: https://doi.org/10.1007/978-1-4612-4594-0_24

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8941-8

  • Online ISBN: 978-1-4612-4594-0

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