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G-CSF as a Differentiation-Inducing Agent in Normal and Leukemic Myelopoiesis

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Tumor Cell Differentiation

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 17))

Abstract

The “reversal of malignancy” in leukemia, while an attractive goal, is one that is rarely attainable in its entirety in clinical or experimental systems. What is more feasible and has proved attainable, is removal of the maturation block in the leukemic lineage with resulting development of varying but incomplete functional and phenotypic features of lineage-specific differentiation.

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Author information

Authors and Affiliations

  1. Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Malcolm A. S. Moore

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  1. Malcolm A. S. Moore
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsö, Tromsö, Norway

    Jarle Aarbakke

  2. Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC, USA

    Peter K. Chiang

  3. University of California, Los Angeles, California, USA

    H. Phillip Koeffler

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© 1987 The Humana Press Inc.

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Moore, M.A.S. (1987). G-CSF as a Differentiation-Inducing Agent in Normal and Leukemic Myelopoiesis. In: Aarbakke, J., Chiang, P.K., Koeffler, H.P. (eds) Tumor Cell Differentiation. Experimental Biology and Medicine, vol 17. Humana Press. https://doi.org/10.1007/978-1-4612-4594-0_2

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  • DOI: https://doi.org/10.1007/978-1-4612-4594-0_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8941-8

  • Online ISBN: 978-1-4612-4594-0

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