Skip to main content
SpringerLink
Log in

Does Induction of Differentiation Have a Role in the Maintenance of Remission in Acute Myelogenous Leukemia in Children?

  • Chapter
Tumor Cell Differentiation

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 17))

  • 49 Accesses

Abstract

Acute myelogenous leukemia (AML) in children is considerably more resistant to chemotherapy than acute lymphoblastic leukemia where the progress is well known and well documented (1,2). In recent years, however, more aggressive chemotherapy has resulted in an increasing proportion of children who obtain a complete remission. With intensive consolidation therapy, the proportion of children remaining in complete remission is also increasing, but long-term survival figures of more than 40% has not been reported (3–5).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Riehm, H., Feickert, H.-J. and Lampert, F. (1986). Acute lymphoblastic leukaemia. In cancer in children. Clinical management (P.A. Voute, A. Barrett, H.J.G. Bloom, J. Lemerle M.K. Neiderhardt eds.). Heidelberg: Springer-Verlag, 101–18

    Google Scholar 

  2. Lampkin, B.C., Woods, W., Strauss, R. et al (1983) Blood 61, 215–28

    PubMed  CAS  Google Scholar 

  3. Weinstein, H.J., Mayer, R.H., Rosenthal, D.S. et al (1980) N Eng J Med 303, 473–484

    Article  CAS  Google Scholar 

  4. Preisler, H.D., Brecher, M., Browman, G. et al (1982) Am J Haematol 13, 189–198

    Article  CAS  Google Scholar 

  5. Creutzig, U., Ritter, J., Riehm, H. et al (1985) Blood 65, 298–304

    PubMed  CAS  Google Scholar 

  6. Lie, S.O. and Slørdahl, S.H (1984) Scand J Haematol 33, 256–259

    Article  PubMed  CAS  Google Scholar 

  7. Lie, S.O. and Slørdahl, S.H. (1985) Seminars in Oncology 12, suppl. 3, 160–165

    PubMed  CAS  Google Scholar 

  8. Trouet, A., Deprez-de Campeneere, D. and Duve, C. de. (1972) Nature 239, 110–111

    Article  CAS  Google Scholar 

  9. Lie, S.O., Lie, K.K. and Glomstein, A. (1979) Cancer Chemother Pharmacol 2, 61–66

    Article  PubMed  CAS  Google Scholar 

  10. Olson, J.A. (1983) Seminars in Oncology 9, 290–293

    Google Scholar 

  11. Goodman, S.D. (1984) New Engl J Med 310, 1023–1031

    Article  PubMed  CAS  Google Scholar 

  12. McCulloch, E.A. (1983) Blood 62, 1–13

    PubMed  CAS  Google Scholar 

  13. Greaves, M.F., Chan, L.C., Furley, A.J.W., Watt, S.M. and Molgaard, H.V. (1986) Blood 67, 1–11

    Google Scholar 

  14. Breitman, T.R., Selonic, S.E. and Collins, S.J. (1980) Proc Natl Acad Sci USA 77, 2936–2939

    Article  PubMed  CAS  Google Scholar 

  15. Sachs, L. (1985) Haematol Blood Transf 29, 353–362

    CAS  Google Scholar 

  16. Koeffler, H.P. (1983) Blood 62, 709–21

    PubMed  CAS  Google Scholar 

  17. Sporn, M.B., Roberts, A.B. and Goodman, D.S. (1984) The Retinoids, Vol 1 & 2, Academic Press Inc.

    Google Scholar 

  18. Douer, D. and Koeffler, H.P. (1982) Exp Cell Res 138, 193–198

    Article  PubMed  CAS  Google Scholar 

  19. Findley, H.W. jr., Steuber, C.P., Ruymann, F.B., Culbert, S. and Ragab, A.H. (1984) Exp Hematol 12, 768–773

    PubMed  Google Scholar 

  20. Lotan, R. (1980) Biomed Biophys Acta 605, 33–91

    CAS  Google Scholar 

  21. Lotem, J., Berrebi, A. and Sachs, L (1985) Leukemia Res 9, 249–258

    Article  CAS  Google Scholar 

  22. Reiss, M., Gamba-Vitalo, C. and Sartorelli, A.C. (1986) Cancer Treat Rep 70, 201–218

    PubMed  CAS  Google Scholar 

  23. Findley, H.W. jr., Steuber, C.P., Buymann F.B., McKolanis, J.R., Williams, D.L. and Ragab, A.H. (1986) Leukemia Res 10, 43–50

    Article  Google Scholar 

  24. Flynn, P.J., Miller, W.J., Weisdorf, D.J., Arthur, C.C., Brunning, R. and Branda, R.F. (1983) Blood 62, 1211–1217

    PubMed  CAS  Google Scholar 

  25. Fontana, J.A., Rogers, J.S. and Durham, J.P. (1986) Cancer 57, 209–217

    Article  PubMed  CAS  Google Scholar 

  26. Gold, E.J., Mertelsmann, R.H., Itri, L.M., Gee, T., Arlin, Z., Kempin, S., Clarkson, B. and Moore, M.A.S (1983) Cancer Treat Rep 67, 981–986

    PubMed  CAS  Google Scholar 

  27. Daenen, S., Vellenga, E., Dobbenburg, O.A. van and Haile, M.R. (1986) Blood 67, 559–561

    PubMed  CAS  Google Scholar 

  28. Dharmasena, F. and Galton, D.A.G (1986) Brit J Haematol 63, 211–213

    Article  CAS  Google Scholar 

  29. Consolini, R., Breard, J., Bourinbaiar, A., Goutner, A., Georgoulias, W., Canon, C., Bruserie, E. and Mathé, G. (1986) Blood 67, 796–801

    PubMed  CAS  Google Scholar 

  30. Fearon, E.R., Burke, P.J., Schiffer, C.A., Zehnbauer, B.A. and Vogelstein, B. (1986) N Engl J Med 315, 15–23

    Article  PubMed  CAS  Google Scholar 

  31. Rifkind, R.A. (1986) N Engl J Med 315, 56–57

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pediatric Research Institute, Rikshospitalet, 0027, Oslo 1, Norway

    Sverre O. Lie

Authors
  1. Sverre O. Lie
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, Institute of Medical Biology, University of Tromsö, Tromsö, Norway

    Jarle Aarbakke

  2. Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC, USA

    Peter K. Chiang

  3. University of California, Los Angeles, California, USA

    H. Phillip Koeffler

Rights and permissions

Reprints and permissions

Copyright information

© 1987 The Humana Press Inc.

About this chapter

Cite this chapter

Lie, S.O. (1987). Does Induction of Differentiation Have a Role in the Maintenance of Remission in Acute Myelogenous Leukemia in Children?. In: Aarbakke, J., Chiang, P.K., Koeffler, H.P. (eds) Tumor Cell Differentiation. Experimental Biology and Medicine, vol 17. Humana Press. https://doi.org/10.1007/978-1-4612-4594-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4594-0_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8941-8

  • Online ISBN: 978-1-4612-4594-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation