Induction of Nonspecific Suppressor Cells by Different Epstein-Barr Virus Antigens

  • Syam K. Sundar
  • José Menezes
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)


We have examined in vitro the interaction of different Epstein-Barr virus (EBV) and other unrelated antigens and observed that non-specific suppressor T (Ts) cells can be generated under the following conditions: simultaneous presence of the antigen-specific Ts cell-inducing antigen and other unrelated (or multiple) antigens to which the test lymphocytes have been sensitized. Such a phenomenon may be responsible for inducing nonspecific Ts cells in vivo (e.g. infections and malignancies).




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  1. 1.
    K.S. Sundar and J. Menezes. Int. J. Cancer. 35, 351 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    B.F. Haynes et al. J. Immunol. 123, 2095 (1979).Google Scholar
  3. 3.
    H.E. Johnsen et al. J. Immunol. 10, 251 (1979).Google Scholar
  4. 4.
    E.L. Reinhertz et al. J. Immunol. 125, 1269 (1980).Google Scholar
  5. 5.
    We thank the Canadian Medical Research Council for financial support.Google Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Syam K. Sundar
    • 1
  • José Menezes
    • 1
  1. 1.Laboratory of ImmunovirologyUniversity of Montreal and Ste-Justine HospitalMontrealCanada

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