Induction of Nonspecific Suppressor Cells by Different Epstein-Barr Virus Antigens
We have examined in vitro the interaction of different Epstein-Barr virus (EBV) and other unrelated antigens and observed that non-specific suppressor T (Ts) cells can be generated under the following conditions: simultaneous presence of the antigen-specific Ts cell-inducing antigen and other unrelated (or multiple) antigens to which the test lymphocytes have been sensitized. Such a phenomenon may be responsible for inducing nonspecific Ts cells in vivo (e.g. infections and malignancies).
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