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Epstein-Barr Virus and Human Disease pp 331–332Cite as

Polyclonal Activation of B Lymphocytes after EB Virus Infection

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Part of the book series: Experimental Biology and Medicine ((EBAM,volume 15))

Abstract

CD23 (Blast-2) is a 45k protein which is a B cell activation antigen appearing early after EB virus infection1 It is then shed from the surface as a 33k protein (s-Blast-2) which is thought to act as a growth factor for activated B cells.2 Separation of CD23+ and CD23- B cell fractions shortly after infection gives a population of immortalised cells (CD23+) and a non-immortalised population (CD23-)3. CD 20 is a 35k protein present on all B cells. Anti-CD20-antibody, B1, inhibits activation of B cells by pokeweed mitogen but not by the phorbol ester, TPA4. We have studied the effect of anti-CD23 antibody (MHM6) and anti-CD20-antibody, (B1) on B cell activation, immortalisation and immunoglobulin (Ig) production by EB virus.

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References

  1. Thorley-Lawson D.A., et al. J.Immunol. 134, No.5 3007 (1985).

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  2. Swendeman S.L. and Thorley-Lawson D.A. Abstract at the 11th INTERNATIONAL HERPES VIRUS MEETING, LEEDS, JULY 1985.

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  3. Thorley-Lawson D.A., et al. J.Exp.Med. 162, 45 (1985).

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  4. Tedder T.F., et al. Eur.J.Immunol. 16:881 (1986).

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Author information

Authors and Affiliations

  1. Dept. of Haematology, UCL Medical School, London, UK

    T. Azim

  2. Dept. of Virology, Royal Post-Graduate Medical School, London, UK

    J. Golay, K. Lam & D. H. Crawford

Authors
  1. T. Azim
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  2. J. Golay
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  3. K. Lam
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  4. D. H. Crawford
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Editor information

Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    P. H. Levine  & D. V. Ablashi  & 

  2. Showa University Research Institute, St. Petersburg, Florida, USA

    M. Nonoyama

  3. Georgetown University Medical Center, Washington, D C, USA

    G. R. Pearson

  4. The Ohio State University, Columbus, Ohio, USA

    R. Glaser

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© 1987 The Humana Press Inc.

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Azim, T., Golay, J., Lam, K., Crawford, D.H. (1987). Polyclonal Activation of B Lymphocytes after EB Virus Infection. In: Levine, P.H., Ablashi, D.V., Nonoyama, M., Pearson, G.R., Glaser, R. (eds) Epstein-Barr Virus and Human Disease. Experimental Biology and Medicine, vol 15. Humana Press. https://doi.org/10.1007/978-1-4612-4590-2_72

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  • DOI: https://doi.org/10.1007/978-1-4612-4590-2_72

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8940-1

  • Online ISBN: 978-1-4612-4590-2

  • eBook Packages: Springer Book Archive

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