A Nude-Mouse-Grown NPC Tumor Produces Interleukin-1
IL-1 is the term currently accepted for a cytokine which has a variety of important pleomorphic functions in immuno-regulation and inflammation (1). It plays a central role in T cell activation, mainly through induction of IL-2 secretion by activated T cells.
KeywordsAutocrine Growth Factor Malignant Epithelial Cell Crude Supernatant
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References and Notes
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- 8.We thank Dr T. Kasahara (Jichi Medical school, Japan) for generous gift of anti-IL-1 polyclonal serum, Otsuka Pharmaceutical (Tokoshima, Japan) for generous gift of IL-1 cDNA probe, and anti IL-1 polyclonal serum, Dainippon Pharmaceutical (Osaka, Japan) for IL-1 cDNA probe, and Dr C. Dinarello (Tufts University, U.S.A.) for anti human IL-1 polyclonal serum. P. Busson was the recipient of a grant from Institut Gustave-Roussy, Villejuif, France. This work was partially supported by a grant form the Centre National de la Recherche Scientifique (CNRS), Paris, France (Grant No 95–75–17, ATP oncogenes).Google Scholar