Prognostic Significance of Serial EBV Antibody Titers in Treated Nasopharyngeal Carcinoma Patients

  • Roger R. Connelly
  • Paul H. Levine
  • Gregory Milman
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Abstract

Antibody titers to Epstein-Barr virus (EBV) antigens among nasopharyngeal carcinoma (NPC) patients may fluctuate during the course of disease. An assay pattern that is predictive of treatment effectiveness would be very useful for monitoring patients. Analyses of serial antibody titers are often complicated by censorship of the time to response. All patients will not experience the response of interest, e.g., death or disease recurrence, before the time of analysis. Another problem is that serial antibody titers are only measured at relatively infrequent intervals during follow-up. These problems are accommodated by the proportional hazards model with titer measurements treated as a time-dependent covariate. This model was used to evaluate the prognostic significance of antibody titers to EBV nuclear antigen (EBNA) and early antigen (EA) in treated NPC patients.

Keywords

Stratification Carol Sylvan 

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Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Roger R. Connelly
    • 1
  • Paul H. Levine
    • 2
  • Gregory Milman
    • 3
  1. 1.Biometry BranchNational Cancer InstituteBethesdaUSA
  2. 2.Environmental Epidemiology BranchNCIBethesdaUSA
  3. 3.Dept. of BiochemistryThe Johns Hopkins Univ.BaltimoreUSA

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