Regulation of EBV Lytic Cycle Genes: MS-EA, a Trans-Activator of Gene Expression

Lieberman, P. M.; Cho, M.-S.; Hayward, S. D.

doi:10.1007/978-1-4612-4590-2_34

P. M. Lieberman⁵,
M.-S. Cho⁵ &
S. D. Hayward⁵

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 15))

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Abstract

We identified one of the products encoded by P3HR-1 defective DNA as a 45/60 kd family of polypeptides which mapped to the BMLF1/BSLF2 open reading frames. We termed this product MS-EA. In transient expression assays, both wild-type and defective DNA encoded MS-EA were found to activate expression from a variety of promoter-CAT constructs. Thus MS-EA has the properties of a generalized trans-activator.

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References and Notes

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Authors and Affiliations

Dept. of Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
P. M. Lieberman, M.-S. Cho & S. D. Hayward

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P. M. Lieberman
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M.-S. Cho
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S. D. Hayward
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Editors and Affiliations

National Cancer Institute, Bethesda, Maryland, USA
P. H. Levine & D. V. Ablashi &
Showa University Research Institute, St. Petersburg, Florida, USA
M. Nonoyama
Georgetown University Medical Center, Washington, D C, USA
G. R. Pearson
The Ohio State University, Columbus, Ohio, USA
R. Glaser

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Lieberman, P.M., Cho, MS., Hayward, S.D. (1987). Regulation of EBV Lytic Cycle Genes: MS-EA, a Trans-Activator of Gene Expression. In: Levine, P.H., Ablashi, D.V., Nonoyama, M., Pearson, G.R., Glaser, R. (eds) Epstein-Barr Virus and Human Disease. Experimental Biology and Medicine, vol 15. Humana Press. https://doi.org/10.1007/978-1-4612-4590-2_34

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DOI: https://doi.org/10.1007/978-1-4612-4590-2_34
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8940-1
Online ISBN: 978-1-4612-4590-2
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