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Chronic active Epstein-Barr virus infection in children: heterogeneity in immune defects and EBNA-antibody pattern

  • W. Kuis
  • A. L. Young
  • A. B. Rickinson
  • E. R. de Graeff-Meeder
  • G. T. Rijkers
  • B. J. M. Zegers
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Abstract

Ballow et al. (1) and Tobi et al. (2) were the first to describe the clinical characteristics of a number of patients with chronic active Epstein-Barr Virus (EBV) infection. The patients displayed the following features: chronic or recurrent infectious mononucleosis-like symptoms lasting for a period of at least one year, abnormal humoral immune response to EBV, i.e. high IgG and IgA antibody titers against EBV capsid antigen (VCA) and persistently elevated antibodies against early antigen (EA). Moreover no pre-existent immunological abnormality or any other underlying disease could be demonstrated.

Keywords

Immune Defect Early Antigen Suppressor Cell Function EBNA Protein Plasma Cell Generation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    M. Ballow et al., Ann. Intern. Med. 6: 821, 1982Google Scholar
  2. 2.
    M. Tobi et al., Lancet 1: 62, 1982Google Scholar
  3. 3.
    W. Kuis et al., J. of Clin. Immunol. 5: 377, 1985CrossRefGoogle Scholar
  4. 4.
    D. Rowe et al., EMBO Journal, in pressGoogle Scholar
  5. 5.
    L.K. Borysiewicz et al., Quart. J. of Med. 58: 111, 1986Google Scholar
  6. 6.
    J.D. Fingeroth et al., P.N.A.S. 81: 4510, 1984PubMedCrossRefGoogle Scholar
  7. 7.
    G. Tosato et al., J. of Immunol. 134: 3082, 1985Google Scholar
  8. 8.
    G. Miller et al., New Eng. J. of Med. 312:750, 1985CrossRefGoogle Scholar
  9. 9.
    T. Dambaugh et al.,P.N.A.S. 81: 7632, 1984PubMedCrossRefGoogle Scholar
  10. 10.
    K. Hennessy et al., P.N.A.S. 82: 5944, 1985PubMedCrossRefGoogle Scholar
  11. 11.
    A.B. Rickinson, Immunol Today 7: 13, 1986CrossRefGoogle Scholar

Copyright information

© THe Humana Press Inc. 1987

Authors and Affiliations

  • W. Kuis
    • 1
  • A. L. Young
    • 2
  • A. B. Rickinson
    • 2
  • E. R. de Graeff-Meeder
    • 1
  • G. T. Rijkers
    • 1
  • B. J. M. Zegers
    • 1
  1. 1.University Hospital for Children and Youth “Het Wilhelmina Kinderziekenhuis”UtrechtThe Netherlands
  2. 2.Department of Cancerstudies, Medical SchoolUniversity of BirminghamBirminghamUK

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