Chronic active Epstein-Barr virus infection in children: heterogeneity in immune defects and EBNA-antibody pattern
Ballow et al. (1) and Tobi et al. (2) were the first to describe the clinical characteristics of a number of patients with chronic active Epstein-Barr Virus (EBV) infection. The patients displayed the following features: chronic or recurrent infectious mononucleosis-like symptoms lasting for a period of at least one year, abnormal humoral immune response to EBV, i.e. high IgG and IgA antibody titers against EBV capsid antigen (VCA) and persistently elevated antibodies against early antigen (EA). Moreover no pre-existent immunological abnormality or any other underlying disease could be demonstrated.
KeywordsImmune Defect Early Antigen Suppressor Cell Function EBNA Protein Plasma Cell Generation
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- 1.M. Ballow et al., Ann. Intern. Med. 6: 821, 1982Google Scholar
- 2.M. Tobi et al., Lancet 1: 62, 1982Google Scholar
- 4.D. Rowe et al., EMBO Journal, in pressGoogle Scholar
- 5.L.K. Borysiewicz et al., Quart. J. of Med. 58: 111, 1986Google Scholar
- 7.G. Tosato et al., J. of Immunol. 134: 3082, 1985Google Scholar