Abstract
EBV is classically associated with infectious mononucleosis, Burkitt’s lympyoma and nasopharyngeal carcinoma (1). More recently, this virus has been associated with development of B-cell lympyhomas in immunocompromised individuals (2). Many clinical illnesses which are not readily recognized as being due to or associated with EBV are missed because of lack of standard laboratory findings that physicians generally associate with infectious mononucleosis. One such group of patients have a severe chronic illness, associated with extraordinarily high anti-VCA (≥10,000) and EA (≥640) antibody titers (3).
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References
Epstein MA, Achong BG. Introduction: Discovery and general biology of the virus. In: Epstein MA, Achong EB, eds. The Epstein-Barr Virus. Berlin: Springer Verlag, 1979: 1–22.
Hanto DW, Sakamoto K, Purtilo DT, et al. The Epstein-Barr virus in the pathogenesis of post-transplant lymphoproliferative disorders; clinical, pathological and virologic correlation. Surgery 1981; 90:204–213.
Tobi M, Straus SE. Chronic Epstein-Barr virus disease: A workshop held by the National Institute of Allergy and Infectious Disease. Ann Intern Med 1985; 103:951–953.
Jones JF, Ray CG, Minnich LL, et al. Evidence for active Epstein-Barr virus infection in patients with persistent unexplained illnesses: Elevated anti-early antigen antibodies. Ann Intern Med 1985; 102:1–7.
Alfieri C, Ghibu F, Joncas JH. Lytic, non-transforming Epstein-Barr virus (EBV) from a patient with chronic active EBV infection. Can Med Assoc J 1984; 131:1249–1252.
Miller G, Grogan E, Fischer DK, et al. Antibody responses to two Epstein-Barr nuclear antigens defined by gene transfer. New Engl J Med 1985; 312:750–755.
Sheibani K, Tubbs RR. Enzyme immunohistochemistry: Technical aspects. Sem Diag Pathol 1984; 1:235–250.
Aisenberg AC, Krontiris TG, Mak TW, Wilkes BM. Rearrangement of the gene for beta chain of the T-cell receptor in T-cell chronic lymphocytic leukemia and related disorders. New Engl J Med 1985; 313:529–533.
Cleary ML, Chad J, Warnke R, Sklar J. Immunoglobulin gene rearrangement as a diagnostic criterion of B-cell lymphoma. Proc Natl Acad Sci USA 1984; 81:593–597.
Weiss LM, Wood GS, Trela MJ, et al. Clonal T cell populations in lymphomatoid papulosis: Evidence for a lymphoproliferative etiology in a clinically benign disease. New Engl J Med 1986; 315:375–494.
Sklar J, Cleary MC, Thielemans K, et al. Biclonal B-cell lymphoma. New Engl 3 Med 1984; 311:20–27.
Fischer DK, Miller G, Gradoville L, et al. Genoma of a mononucleosis Epstein-Barr virus contains DNA fragments previously regarded to be unique to Burkitt’s lymphoma isolates. Cell 1981; 543–553.
Skare J, Edson C, Farley J, Strominger JL. The B95–8 isolate of Epstein-Barr virus arose from an isolate with a standard genome. J Virology 1982; 44:1088–1091.
Brigati Dj, Myerson D, Leary JJ, et al. Detection of viral genomes and cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes. Virology 1983; 126:32–50.
Haase A, Brahic M, Stowring L, Blum H. Detection of viral nucleic acids by in situ hybridization probes. Methods in Virology 1984; 7:189–226.
Fingeroth JD, Weis JJ, Tedder RF, et al. Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci USA 1984; 81:4510–4514.
Shore A, Dosch H-M, Gelfand EW. Expression and modulation of C3 receptors during early T-cell ontogeny. Cell Immunol 1979; 45:157–166.
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© 1987 The Humana Press Inc.
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Jones, J.F., Shurin, S., Abramowsky, C., Katz, B., Sklar, J. (1987). T Cell Lymphomas in Patients with Chronic EBV Infection. In: Levine, P.H., Ablashi, D.V., Nonoyama, M., Pearson, G.R., Glaser, R. (eds) Epstein-Barr Virus and Human Disease. Experimental Biology and Medicine, vol 15. Humana Press. https://doi.org/10.1007/978-1-4612-4590-2_20
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DOI: https://doi.org/10.1007/978-1-4612-4590-2_20
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8940-1
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