Endothelium-Dependent Contractions in Veins and Arteries
While searching for possible heterogeneity of endothelium-dependent relaxations to acetylchloride, adenosine diphosphate, arachidonic acid, and thrombin, the author’s laboratory discovered that the endothelial cells not only play an obligatory role in a number of dilator responses (Furchgott and Zawadzki, 1980; Furchgott, 1983, 1984; Vanhoutte et al., 1986), but also can induce contractions of isolated blood vessels when exposed to certain stimuli (De Mey and Vanhoutte, 1982, 1983). This chapter summarizes the data demonstrating that endothelial cells can indeed produce at least two different types of constricting substances (endothelium-derived contracting factors) (see Vanhoutte, 1987a).
KeywordsDepression Adenosine Serotonin Prostaglandin Norepinephrine
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