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Endothelium-Dependent Contractions in Veins and Arteries

  • Paul M. Vanhoutte
Part of the The Endothelium book series (TEEN)

Abstract

While searching for possible heterogeneity of endothelium-dependent relaxations to acetylchloride, adenosine diphosphate, arachidonic acid, and thrombin, the author’s laboratory discovered that the endothelial cells not only play an obligatory role in a number of dilator responses (Furchgott and Zawadzki, 1980; Furchgott, 1983, 1984; Vanhoutte et al., 1986), but also can induce contractions of isolated blood vessels when exposed to certain stimuli (De Mey and Vanhoutte, 1982, 1983). This chapter summarizes the data demonstrating that endothelial cells can indeed produce at least two different types of constricting substances (endothelium-derived contracting factors) (see Vanhoutte, 1987a).

Keywords

Arachidonic Acid Pulmonary Vein Basilar Artery Contractile Response Adenosine Diphosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© The Humana Press Inc. 1988

Authors and Affiliations

  • Paul M. Vanhoutte

There are no affiliations available

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