Endothelium-Dependent Responses in the Peripheral Microcirculation

  • T. M. Griffith
  • D. H. Edwards
  • R. L. Davies
  • T. J. Harrison
  • K. T. Evans
Part of the The Endothelium book series (TEEN)


Experimental studies of endothelium-dependent relaxation have to date largely focused on the properties of pharmacologically and physiologically vasoactive agents in conduit vessels. The phenomenon has been demonstrated in vitro (Furchgott, 1983) and in vivo (Angus et al., 1983), although it has become apparent that species and vessel differences exist (Furchgott, 1983; Kalsner, 1985; Katusic et al., 1984). There is evidence that injury to the arterial wall, as occurs in experimental models of atheroma (Habib et al., 1984) or hypertension (Konishi and Su, 1983), may functionally impair endothelium-dependent responses. These observations may have clinical relevance. Relatively little is known, however, about endothelium-dependent relaxation in the microvasculature, where it may have an important physiological role, since small vessels regulate peripheral resistance and hence govern the distribution of blood flow in the intact circulation.


Vessel Diameter Vasoactive Intestinal Polypeptide Resistance Vessel Branch Vessel Central Artery 
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Copyright information

© The Humana Press Inc. 1988

Authors and Affiliations

  • T. M. Griffith
  • D. H. Edwards
  • R. L. Davies
  • T. J. Harrison
  • K. T. Evans

There are no affiliations available

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