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Relaxing and Contracting Factors pp 189–217Cite as

Release of Endothelium-Derived Relaxing Factor(s) by Physicochemical Stimuli

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Part of the book series: The Endothelium ((TEEN))

Abstract

When Furchgott and Zawadzki (1980) published their pioneering observations on endothelium-dependent vascular responses, their results looked somewhat like a biological curiosity. Most of the endothelial stimulators do not circulate and therefore do not reach the endothelium from the luminal side in significant concentrations. The principal stimulator, acetylcholine, is rapidly inactivated by cholinesterases. Obviously, the biological concept and physiological relevance of endothelium-stimulated vasomotion by serotonin, norepinephrine, thrombin, substance P, bradykinin, adenosine triphosphate (ATP), and diphosphate (ADP) is not well understood so far. From this uncertainty, the question arises as to whether endothelium-dependent vasomotion plays a significant role in the regulation of blood flow to the organs under physiological or pathophysiological conditions. If such regulation plays a significant part, one would expect a continuous basal release of endothelium-derived vasoactive compounds, which would be effectively modulated or amplified by a number of physiological activators like metabolites, changes in PO2 and PCO2 (or pH), and similar parameters affected by increased activity of the tissues. Such basal release has indeed benn demonstrated, and various physiological factor associated with increased activity of the organs have a modulatory role on the continuous liberation of endothelium-derived relaxing factor (EDRF).

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Authors
  1. Eberhard Bassenge
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  2. Rudi Busse
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  3. Ulrich Pohl
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Editors and Affiliations

  1. Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

    Paul M. Vanhoutte

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Bassenge, E., Busse, R., Pohl, U. (1988). Release of Endothelium-Derived Relaxing Factor(s) by Physicochemical Stimuli. In: Vanhoutte, P.M. (eds) Relaxing and Contracting Factors. The Endothelium. Humana Press. https://doi.org/10.1007/978-1-4612-4588-9_10

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  • DOI: https://doi.org/10.1007/978-1-4612-4588-9_10

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