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Tumor Necrosis Factors Alpha and Beta

A Family of Biochemically Related Cytokines

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Leukolysins and Cancer

Part of the book series: Contemporary Biomedicine ((CB,volume 8))

Abstract

In 1891, a surgeon, William Coley, working at The Memorial Hospital in New York City observed the disappearance of a neck tumor in a patient who had contracted erysipelas, a streptococcal infection (1). Thirty eight additional cases dating back to 1868 were also documented by Coley, who then decided to treat other cancer patients with live streptococci. Because this was not “acceptable” medical practice at the time, however, heat-killed organisms were used instead. This approach failed.

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Authors
  1. Michael A. Palladino Jr.
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  2. Arthur J. Ammann
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Editor information

Editors and Affiliations

  1. Bionetics Research Inc., Rockville, Maryland, USA

    Janet H. Ransom

  2. Biological Therapeutics Branch, Biological Response Modifiers Program, Division of Cancer Treatmen, National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland, USA

    John R. Ortaldo

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© 1988 The Humana Press Inc.

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Palladino, M.A., Ammann, A.J. (1988). Tumor Necrosis Factors Alpha and Beta. In: Ransom, J.H., Ortaldo, J.R. (eds) Leukolysins and Cancer. Contemporary Biomedicine, vol 8. Humana Press. https://doi.org/10.1007/978-1-4612-4586-5_13

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  • DOI: https://doi.org/10.1007/978-1-4612-4586-5_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8938-8

  • Online ISBN: 978-1-4612-4586-5

  • eBook Packages: Springer Book Archive

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