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Copper-Dependent α-Amidation in the Synthesis of Neuroendocrine Peptide Hormones

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Biology of Copper Complexes

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 16))

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Abstract

The absolute requirement for copper by many enzymes and biological processes has been well established. The low activity in vitro of many copper-requiring enzymes has been shown to be responsible for symptoms associated with copper deficiency. Among these are altered mental status due to changes in norepinephrine levels (dopamine β-hydroxylase)1, loss of hair pigmentation (tyrosinase)2, and reduced bone and artery competence (lysyl oxidase)3. In addition, the symptoms of copper deficiency include other manifestations of neurological dysfunction.4

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Author information

Authors and Affiliations

  1. Mol. Biology Institute and Dept. of Biology, San Diego State University, San Diego, CA, 92182, USA

    Thomas R. Gibson & Christopher C. Glembotski

Authors
  1. Thomas R. Gibson
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  2. Christopher C. Glembotski
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Editor information

Editors and Affiliations

  1. University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    John R. J. Sorenson

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© 1987 The Humana Press Inc.

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Gibson, T.R., Glembotski, C.C. (1987). Copper-Dependent α-Amidation in the Synthesis of Neuroendocrine Peptide Hormones. In: Sorenson, J.R.J. (eds) Biology of Copper Complexes. Experimental Biology and Medicine, vol 16. Humana Press. https://doi.org/10.1007/978-1-4612-4584-1_8

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  • DOI: https://doi.org/10.1007/978-1-4612-4584-1_8

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8937-1

  • Online ISBN: 978-1-4612-4584-1

  • eBook Packages: Springer Book Archive

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