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Copper and Connective Tissue: The Mechanism of Lysyl Oxidase

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Biology of Copper Complexes

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 16))

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Abstract

It has long been known that there is a relationship between copper-deficiency and solubilization of connective tissue. Although copper deficiency in humans is not common, cases have been reported in populations that subsist largely on a grain diet, and in such populations there has been noted a high incidence of musculo-skeletal weaknesses attributed to solubilization of collagen and elastin, the proteins of connective tissue. These are proteins with very organized structures. They are very strong and quite insoluble because of extensive cross-linking of the protein chains. As the degree of cross-linking decreases, the proteins become increasingly soluble. Several diseases and some inherited disorders are also characterized by solubilization of connective tissue and it is significant that these are also associated with abnormal copper distributions. Several recent reviews of the physiological aspects of copper are available1.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Clark University, Worcester, MA, 01610, USA

    Frederick T. Greenaway & Coleen Young O’Gara

Authors
  1. Frederick T. Greenaway
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  2. Coleen Young O’Gara
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Editor information

Editors and Affiliations

  1. University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    John R. J. Sorenson

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© 1987 The Humana Press Inc.

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Greenaway, F.T., O’Gara, C.Y. (1987). Copper and Connective Tissue: The Mechanism of Lysyl Oxidase. In: Sorenson, J.R.J. (eds) Biology of Copper Complexes. Experimental Biology and Medicine, vol 16. Humana Press. https://doi.org/10.1007/978-1-4612-4584-1_6

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  • DOI: https://doi.org/10.1007/978-1-4612-4584-1_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8937-1

  • Online ISBN: 978-1-4612-4584-1

  • eBook Packages: Springer Book Archive

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