Radioprotectant Effects of Cu(II)(3,5-DIPS)2

  • Hamid Salari
  • Max L. Baker
  • John B. Barnett
  • Lee S. F. Soderberg
  • William M. Willingham
  • John R. J. Sorenson
Part of the Experimental Biology and Medicine book series (EBAM, volume 16)

Abstract

Ionizing radiation of oxygenated aqueous solution is known to produce superoxide as a secondary product of radiation,1–3 Part of the cellular injuries caused by radiation can be attributed to the acute increase of superoxide. Addition of Cu-Zn superoxide dismutase (Cu-Zn SOD) to the extracellular medium can significantly protect cultured cells against radiation damage.4 Adding Cu-Zn SOD to cultures of myoblasts protected them from a radiation-induced decrease in viability and altered morphology5 as well as chromosomal damage.6

Keywords

Toxicity Hydrated Hydroxyl Cage Propylene 

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Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Hamid Salari
    • 1
    • 2
  • Max L. Baker
    • 2
  • John B. Barnett
    • 3
  • Lee S. F. Soderberg
    • 3
  • William M. Willingham
    • 4
  • John R. J. Sorenson
    • 1
  1. 1.Department of Biopharmaceutical Sciences, College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of Radiology, College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockUSA
  3. 3.Department of Microbiology and Immunology, College of MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA
  4. 4.Department of Natural SciencesUniversity of Arkansas at Pine BluffPine BluffUSA

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