Abstract
In 1979, Oberley and Buettner published a review1 which suggested that all neoplastic cells were deficient in total superoxide dismutase (SOD) activity. To determine whether or not Cu-Zn SOD had an anticancer effect, Oberley and Leuthauser injected mi ce wi th a single dose of this enzyme one hour after they implanted Sarcoma 180 tumor cells in the hind limb of CF1 mice and measured average leg diameter versus time after implantation. In animals treated with saline, tumor growth was unimpeded.2 Animals treated with Cu-Zn SOD showed a reduction in tumor growth. Animals treated with Cu-Zn SOD also showed a slight increase in survival in comparison to those treated only with saline-vehicle.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Oberley, LW; Buettner, GR. Cancer Res. 1979, 39, 1141.
Oberley, LW; Leuthauser, SWHC; Buettner, GR; Sorenson, JRJ; Oberley, TD; Bize, IB. In: Pathology of Oxygen, Academic Press; New York NY, 1982; p 207.
DeAlvare, LR; Goda, K; Kimura T. Biochen. Biophys. Res. Comm. 1976, 69, 687.
Brigelius, R; Spottl, R; Bors, W; Lengfelder, E; Saran, M; Weser, U. Febs Lett. 1974, 47, 72.
Leuthauser, SWHC. Antitumor activities of superoxide dismutase and copper coordination compounds (Dissertation #8012387); University Microfilms International; Ann Arbor MI, 1979.
Leuthauser, SWC; Oberley, LW; Oberley, TD; Sorenson, JRJ; Ramakrishna, K. J. Nat. Cancer Inst. 1981, 66, 1077.
Sorenson, JRJ; Oberley, LW; Oberley, TD; Leuthauser, SWC; Ramakrishna, K; Vernino, L; Kishore, V. In: Trace Subst. Environ. Health--XVI; University of Missouri; Columbia MO, 1982; p 362.
Sahu, SK. Effects of dexamethasone on neuroblastoma cell differentiation, superoxide dismutase activity, and the possible role of negative oxygen ion on cell differentiation (Dissertation #8012417); University Microfilms International; Ann Arbor MI, 1979.
Kensler, TW; Trush, MA. Biochen. Pharmacol. 1983, 32, 3485.
Solanki, V; Yotti, L; Logani, MK; Slaga, TJ. Carcinogenesis 1984, 5, 129.
Wattenberg, LW. Cancer Res. 1985, 45, 1.
Cerutti, PA. Science 1985, 227, 375.
Copeland, ES. Cancer Res. 1986, 46, 5451.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 The Humana Press Inc.
About this chapter
Cite this chapter
Kasemeier, S.L., Salari, H., Sorenson, J.R.J. (1987). Anticancer Effects of Cu(II)(3,5-Diisopropylsalicylate)2in Mice Inoculated Intramuscularly with Ehrlich Ascites Carcinoma Cells. In: Sorenson, J.R.J. (eds) Biology of Copper Complexes. Experimental Biology and Medicine, vol 16. Humana Press. https://doi.org/10.1007/978-1-4612-4584-1_27
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4584-1_27
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8937-1
Online ISBN: 978-1-4612-4584-1
eBook Packages: Springer Book Archive