Skip to main content
SpringerLink
Log in

Peptides and Opiates in Copper Deficiency

  • Chapter
Biology of Copper Complexes

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 16))

Abstract

A link between copper metabolism and endogenous opiates or their receptors and peptides has been suggested by the work from several laboratories (1–4). In humans, Kolb and Sadee proposed a relationship between copper metabolism, endorphins and schizophrenia (5). Early work in animals have shown that central nervous system disorders such as ataxia, motor incoordination and brain and spinal cord degeneration occur in experimental copper deficiency (6–9). Though not specifically mentioned, it is possible that some alteration in opiates (besides alteration in neurotransmitters) could have occurred. A critical role of copper in the brain development has been suggested by Zimmerman et al. (10). O’Dell et al. have reported decreased concentration of dopamine and norepinephrine in brain in experimental copper deficiency (11–13) and that repletion with copper restores the level of norepinephrine (13).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Marzullo, G; Hine, B. Science 1980, 208, 1173.

    Article  Google Scholar 

  2. Chapman, D.B; Way, E.L. Ann, Rev. Pharmacol. Toxicol. 1980, 20, 553.

    Article  CAS  Google Scholar 

  3. Sadee, W; Pfeiffer, A; Herz, A; J. Neurochem. 1982, 39, 659.

    Article  PubMed  CAS  Google Scholar 

  4. Marangos, P.J; Patel, J., Clark-Rosenberg, R; Martino, A.M. J. Neurochem. 1982, 39, 184.

    Article  PubMed  CAS  Google Scholar 

  5. Kolb, V.M; Sadee, W. Res. Commun. Psychol. Psychiatry Behav. 1983, 8, 343.

    CAS  Google Scholar 

  6. Bennetts, M.W. Aust. Vet. J. 1932, 8, 137 and 183.

    Article  Google Scholar 

  7. Everson, G.J; Tsai, H.C; Wang, T.I. J. Nutr. 1967, 93, 533.

    PubMed  CAS  Google Scholar 

  8. DiPaolo, R.W; Kanfer, J.N; Newberne, P.M. J. Neuropath. Exp. Neurol. 1974, 33, 226.

    Article  CAS  Google Scholar 

  9. Carlton, W.W; Kelly, W.A. J. Nutr. 1969, 97, 42.

    PubMed  CAS  Google Scholar 

  10. Zimmerman, A.W; Matthiew, J; Quarles, R.H; Roscoe, B.O; Jing, M.H. Arch. Neurol. 1976, 33, 111.

    PubMed  CAS  Google Scholar 

  11. 0’Dell, B.L. Med. Clin. North Am. 1976, 60, 687.

    PubMed  Google Scholar 

  12. Morgan, R.F; 0’Dell, B.L. J. Neurochem. 1977, 28, 207.

    Article  PubMed  CAS  Google Scholar 

  13. Feller, D.J; 0’Dell, B.L. J. Neurochem. 1980, 34, 1259.

    Article  PubMed  CAS  Google Scholar 

  14. Friedman, S; Kaufman, S. J. Biol. Chem. 1965, 240, 4763.

    CAS  Google Scholar 

  15. Ljones, T; Skotland, T. In: Copper Proteins and Copper Enzymes, Vol. 2; Lontie, R., Ed.; CRC Press, Inc; Boca Raton, FL; 1984; p. 131.

    Google Scholar 

  16. Vaneste, W.H; Zuberbuhler, A. In: Molecular Mechanisms of Oxygen Activation; Hayashi, O., Ed.; Academic Press; New York; 1974, p. 371.

    Google Scholar 

  17. Robb, D.A. In: Copper Proteins and Copper Enzymes, Vol. 2; Lontie, R., Ed.; CRC Press, Inc; Boca Raton, FL; 1984; p. 207.

    Google Scholar 

  18. Mains, R.E; Eipper, B.A. Endocrinol. 1984, 115, 1683.

    Article  CAS  Google Scholar 

  19. Alexander Ross, J.B; Rousslang, K.W; DeHaen, C; Lavis, V.R; Deranleau, D.A. Biochim. Biophys. Acta 1979, 576, 372.

    Google Scholar 

  20. Danks, D.M. In: The Metabolic Basis of Inherited Disease, 5th Ed.; Stanbury, J.B; Wyngaarden, J.B., Fredrickson, D.S., Goldstein, J.L., Brown, M.S., Eds.; McGraw-Hill; New York; 1983, p. 1251.

    Google Scholar 

  21. Ettinger, M.J. In: Copper Proteins and Copper Enzymes, Vol. 2; Lontie, R., Ed.; CRC Press, Inc; Boca Raton, FL; 1984; p. 175.

    Google Scholar 

  22. Formicka-Kozlowska, G; Pettit, L.D., Steel, I., Livera, C.E., Kupryszewski, G., Rolka, K. J. Inorg. Biochem. 1985, 24, 299.

    Article  CAS  Google Scholar 

  23. Sharrock, P; Day, R; Lemaire S; St-Pierre, S; Mazarguil, H; Gairin, J.E; Haran, R. Inorg. Chim. Acta 1982, 66, L91.

    Article  Google Scholar 

  24. Hazum, E. Biochem. Biophys. Res. Commun. 1983, 112, 306.

    Article  PubMed  CAS  Google Scholar 

  25. Viveros, H; Diliberto, E.J., Jr; Hazum, E; Chang, K.J. In: Neural Peptides and Neuronal Communications; Costa, E., Trabucchi, M., Eds.; Raven Press, New York, 1980, p. 191.

    Google Scholar 

  26. Timmers, K; Voyles, N.R; King, C; Wells, M; Fairtile, R; Recant, L. In: Neural and Endocrine Peptides and Receptors; Moody, T., Ed., Plenum Press, 1986 (In Press).

    Google Scholar 

  27. Recant, L; Voyles, N.R; Timmers, K; Zdenski, C; Fields, M; Bhathena, S.J. Peptides (In Press).

    Google Scholar 

  28. Grube, D; Voight, K.H; Weber, E. Histochemistry 1978, 59, 75.

    Article  PubMed  CAS  Google Scholar 

  29. Lolait, S.J; Autelitano, D.J; Marwick, A.J; Toh, B.H; Funder, J.W. Peptides 1986, 7, 267.

    Article  PubMed  CAS  Google Scholar 

  30. Watson, S.J; Akil, H; Fischli, W; Goldstein, A; Zimmerman, E; Nilaver, G; Van Wimersma Greidamus, T.B. Science 1982, 216, 85.

    CAS  Google Scholar 

  31. Anhut, H; Knepel, W. Neurosci. Lett. 1982, 31, 159.

    Article  PubMed  CAS  Google Scholar 

  32. Lundberg, J.M; Martinsson, A; Hemsen, A; Theodorsson-Norheim, E; Svedenhag, J; Ekblom, B; Hjemdahl, P. Biochem. Biophys. Res. Commun. 1985, 133, 30.

    Article  PubMed  CAS  Google Scholar 

  33. Lundberg, J.M; Hokfelt, T; Hemsen, A; Theodorsson-Norheim, E; Pernow, J; Hamberger, B; Goldstein, M. Regulatory Peptides 1986, 13, 169.

    Article  PubMed  CAS  Google Scholar 

  34. Martin, R; Voigt, K.H. Nature 1981, 289, 502.

    Article  PubMed  CAS  Google Scholar 

  35. Meister, B; Hokfelt, T; Vale, W.W; Sawchenko, P.E; Swanson, L; Goldstein, M. Neuroendocrinol. 1986, 42, 237.

    Article  CAS  Google Scholar 

  36. Crouch, R.K; Gandy, S; Patrick, J; Reynolds, S; Buse, M.G; Simson, J.A.V. Exp. Mol. Pathol. 1984, 41, 377.

    Article  PubMed  CAS  Google Scholar 

  37. Tsou, R.C; Dailey, R.A; McLanahan, C.S; Parent, A.D; Tindall, G.T; Neill, J.D. Endocrinol. 1977, 101, 534.

    Article  CAS  Google Scholar 

  38. Burrows, G.H; Barnea, A. Endocrinol. 1982, 110, 1456.

    Article  CAS  Google Scholar 

  39. Allen, D.K; Hasseil, C.A; Lei, K.Y. J. Nutr. 1982, 112, 2043.

    PubMed  CAS  Google Scholar 

  40. Fields, M; Ferretti, R.J; Smith, J.C; Reiser, S. Am. J. Clin. Nutr. 1984, 39, 289.

    PubMed  CAS  Google Scholar 

  41. Fields, M; Feretti, R.J; Reiser, S; Smith, J.C; Jr. Proc. Soc. Exp. Biol. Med. 1984, 175, 530.

    PubMed  CAS  Google Scholar 

  42. Reiser, S; Smith, J.C Jr; Mertz, W; Holbrook, J.T; Scholfield, D.J; Powell, A.S; Canfield, W.K; Canary, J.J. Am. J. Clin. Nutr. 1985, 42, 242.

    PubMed  CAS  Google Scholar 

  43. Bhathena, S.J; Recant, L; Voyles, N.R; Timmers, K.I; Reiser, S; Smith, J.C Jr; Powell, A.S. Am. J. Clin. Nutr. 1986, 43, 42.

    PubMed  CAS  Google Scholar 

  44. Bhathena, S.J; Recant, L; Voyles, N.R; Reiser, S; Smith, J.C; Jr. “unpublished results”

    Google Scholar 

  45. Bhathena, S.J; Voyles, N.R; Timmers, K; Fields, M; Kennedy, B.W; Recant, L. Fed. Proc. 1986, 45, 235.

    Google Scholar 

  46. Bhathena, S.J; Perrino, P.V; Voyles, N.R; Smith, S.S; Wilkins, S.D; Coy, D.H; Schally, A.V; Recant, L. Diabetes 1976, 25, 1031.

    Article  PubMed  CAS  Google Scholar 

  47. Weaver, Fr. C; Sorenson, R.L; Kaung, H.L.C. Diabetes 1986, 35, 13.

    Article  PubMed  CAS  Google Scholar 

  48. Ipp, E; Dhorajiwala, J; Pugh, W; Moosa, A.R; Rubenstein, A.H. Endocrinol. 1982, 111, 2110.

    Google Scholar 

  49. Green, I.C; Perrin, D; Pedley, K.C; Leslie, R.D.G; Pyke, D.A. Diabetologia 1980, 19, 158.

    Article  PubMed  CAS  Google Scholar 

  50. Green, I.C; Ray, K; Perrin, D. Horm. Metabol. Res. 1983, 5, 124.

    Article  Google Scholar 

  51. Hummel, G.M; Bhathena, S.J; Voyles, N.R; Fields, M; Timmers, K; Recant, L. “unpublished results”

    Google Scholar 

  52. Klevay, L.M. In: Metabolism of Trace Metals in Men: Developmental Biology and Genetic Implications, Vol. 1; Rennert, O.M; Chan, W-Y; Eds.; CRC Press, Boca Raton, Fl.; 1984; p. 128.

    Google Scholar 

  53. Fields, M. Int. Med. 1985, 6, 91.

    Google Scholar 

  54. Shenker, Y; Sider, R.S; Ostafin, E.A; Grekin, R.J. J. Clin. Invest. 1985, 76, 1684.

    Article  CAS  Google Scholar 

  55. Tang, J; Song, D.L; Suen, M.Z; Xie, C.W; Chang, D; Chang, J.K. Peptides 1986, 7, 33.

    Article  PubMed  CAS  Google Scholar 

  56. Bhathena, S.J; Zamir, N; Kennedy, B.W; Fields, M. Recant, L. “unpublished results”

    Google Scholar 

  57. Eiden, L.E; Ruth, J.A. Peptides 1982, 3, 475.

    Article  PubMed  CAS  Google Scholar 

  58. Ruth, J.A; Eiden, L.E. Neuopeptides 1984, 4, 101.

    Article  CAS  Google Scholar 

  59. Holaday, J.W. Ann. Rev. Pharmacol. Toxicol. 1983, 23, 541.

    Article  CAS  Google Scholar 

  60. Greenberg, M.J; Painter, S.0; Price, D.A. Neuropeptides 1981, 1, 309.

    CAS  Google Scholar 

  61. Haddad, G.G; Jeng, H.J; Lai, T.L. Am. J. Physiol. 1986, 250, H796.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Carbohydrate Nutrition Laboratory, BHNRC, ARS, USDA, Beltsville, Maryland, 20705, USA

    Sam J. Bhathena

  2. Diabetes Research Laboratory, V.A. Medical Center, Washington, D.C., 20422, USA

    Lillian Recant

Authors
  1. Sam J. Bhathena
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lillian Recant
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    John R. J. Sorenson

Rights and permissions

Reprints and permissions

Copyright information

© 1987 The Humana Press Inc.

About this chapter

Cite this chapter

Bhathena, S.J., Recant, L. (1987). Peptides and Opiates in Copper Deficiency. In: Sorenson, J.R.J. (eds) Biology of Copper Complexes. Experimental Biology and Medicine, vol 16. Humana Press. https://doi.org/10.1007/978-1-4612-4584-1_24

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4584-1_24

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8937-1

  • Online ISBN: 978-1-4612-4584-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation