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Phosphoinositides and alpha-1 Adrenergic Receptors

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The alpha-1 Adrenergic Receptors

Part of the book series: The Receptors ((REC))

Abstract

In 1953, Hokin and Hokin demonstrated that muscarinic cholinergic stimulation of pancreatic fragments increased the turnover of cellular phosphatidylinositol (PI), as measured by an increased incorporation of radioactive phosphorus from inorganic phosphate in the incubation medium (Hokin and Hokin, 1953, 1954). In the 20 yr that followed, the Hokins and other investigators sought to understand the significance of the striking metabolic perturbation to cell function. Many of the early investigations on the “PI effect,” as it came to be called, sought roles for this phenomenon in the specific responses of cells to appropriate extracellular stimuli. However, it soon became obvious that PI turnover was a reaction associated with a wide variety of receptors linked to diverse biological responses. The current view recognizes that accelerated inositol lipid turnover is not involved in specific cellular responses, but is a reaction closely coupled to the activation of certain receptors (including the alpha-1 adrenergic receptor) and represents a general signaling system involving calcium mobilization and activation of protein kinases.

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  1. James W. Putney Jr
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  1. Smith Kline & French Laboratories, Swedeland, Pennsylvania, USA

    Robert R. Ruffolo Jr.

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© 1987 The Humana Press Inc.

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Putney, J.W. (1987). Phosphoinositides and alpha-1 Adrenergic Receptors. In: Ruffolo, R.R. (eds) The alpha-1 Adrenergic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4582-7_5

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  • DOI: https://doi.org/10.1007/978-1-4612-4582-7_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8936-4

  • Online ISBN: 978-1-4612-4582-7

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