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The alpha-1 Adrenergic Receptors pp 113–187Cite as

Ca2+ Utilization in Signal Transformation of alpha-1 Adrenergic Receptors

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Part of the book series: The Receptors ((REC))

Abstract

Alpha-adrenergic receptors play a key role in the regulation of various physiological processes, particularly within the cardiovascular system. Peripheral arteriolar resistance, venous capacitance, and cardiac function can be regulated via peripherally as well as centrally located alpha-adrenergic receptors. It is now well established that alpha-adrenergic receptors do not form a homogeneous population, but can be divided into alpha-1 and alpha-2 subclasses. This chapter will deal with the various mechanisms involved in signal transformation after stimulation of alpha-1 adrenergic receptors, with emphasis directed to the processes involving migration of Ca2+ ions in vascular smooth muscle in vivo and in vitro. When possible and appropriate, a comparison with the calcium utilization of alpha-2 adrenergic receptor-mediated vasoconstriction will be made. For convenience, a concise description of the current classification of alpha-adrenergic receptors is presented here.

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Authors
  1. Pieter B. M. W. M. Timmermans
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  2. Martin J. M. G. Thoolen
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  1. Smith Kline & French Laboratories, Swedeland, Pennsylvania, USA

    Robert R. Ruffolo Jr.

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Timmermans, P.B.M.W.M., Thoolen, M.J.M.G. (1987). Ca2+ Utilization in Signal Transformation of alpha-1 Adrenergic Receptors. In: Ruffolo, R.R. (eds) The alpha-1 Adrenergic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4582-7_4

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  • DOI: https://doi.org/10.1007/978-1-4612-4582-7_4

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