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Biochemistry and Pharmacology of the alpha-1 Adrenergic Receptor

  • Chapter
The alpha-1 Adrenergic Receptors

Part of the book series: The Receptors ((REC))

Abstract

The biochemical and pharmacological characterization of the alpha-1 adrenergic receptor binding site has been dependent upon two advances, one conceptual and the other technical. The conceptual development was the subclassification of alpha-adrenergic receptors into alpha-1 and alpha-2 receptors, as detailed in the first chapter of this book. The technical advance was the development of the radioligand binding technique, which allows the receptor to be studied directly using high-affinity radioligands. It is the intent of this chapter to critically review what we have learned about the biochemistry and pharmacology of the alpha-1 adrenergic receptor since its definition about 10 years ago. The first section will deal with radioligand binding studies in broken cell preparations and will include a review of the various radioligands available, tissue and regional distribution of the receptor binding site, and biochemical characteristics of this receptor site. Subsequent sections will cover radioligand binding in intact cells, solubilization and purification of the receptor, and the structure of the receptor. Several previous reviews have dealt in part with these subjects (Homcy and Graham, 1985; Kunos, 1984; Perry and U’Prichard, 1984; U’Prichard, 1981; Starke, 1981).

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  1. David B. Bylund
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    Robert R. Ruffolo Jr.

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Bylund, D.B. (1987). Biochemistry and Pharmacology of the alpha-1 Adrenergic Receptor. In: Ruffolo, R.R. (eds) The alpha-1 Adrenergic Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4582-7_2

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