Regulation of alpha-1 Adrenergic Receptors
Catecholamines modulate a wide variety of important physiological processes, alpha-1 Adrenergic receptors play a major role in transducing many of the actions of catecholamines. A particularly prominent action of alpha-1 adrenergic receptors is the promotion of vasoconstriction in a range of vascular beds. Additionally these receptors are found in nonvascular smooth muscle such as vas deferens and uterus, as well as in other tissues such as the liver and heart. Although these receptors influence important cellular responses, it is clear that the physiological response to alpha-1 adrenergic receptor activation is not fixed, but may vary in a range of situations. For example, prolonged exposure to catecholamines may modify the effects of subsequent alpha-1 adrenergic receptor activation. Also, changes in hormonal state or disease processes such as hypertension may alter tissue responsiveness to alpha-1 adrenergic receptor-transduced events.
KeywordsAdenosine Serotonin Histamine Norepinephrine Glucocorticoid
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- Carrier, O., Wedel, E. K., Barron, K. W. (1978) Specific alpha-adrenergic receptor desensitization in vascular smooth muscle. Blood Vess. 15, 247–258.Google Scholar
- Colucci, W. S., Brock, T. A., Gimbrone, M. A., Jr., and Alexander, R. W. (1984) Regulation of alpha-1 adrenergic receptor-coupled calcium flux in cultured vascular smooth muscle cells. Hypertension 6 (suppl. I), 119–124.Google Scholar
- Guellaen, G., Yates-Aggerbeck, M., Vauquelin, G., Strosberg, D., and Ha-noune, J. (1978) Characterization with [3H]dihydroergocryptine of the alpha-adrenergic receptor of the hepatic plasma membrane. J. Bio. Chem. 253, 1114–1120.Google Scholar
- Itoh, H., Okajima, F., and Ui, M. (1984) Conversion of adrenergic mechaniam from an alpha- to a beta-type during primary culture of rat hepatocytes: Accompanying decreases in the function of the inhibitory nucleotide regulatory component of adenylate cyclase identified as the substate of islet-activating protein. J. Biol. Chem. 259, 15464–15473.PubMedGoogle Scholar
- Leeb-Lundberg, L. M. F., Cotecchia, S., Lomasney, J. N., DeBernardis, J. F., Lefkowitz, R. J., and Caron, M. G. (1985) Phorbol esters promote alpha-1-adrenergic receptor-phosphorylation and receptor uncoupling from inositol phospholipid metabolism. Proc. Natl. Acad. Sci. USA 82, 5651–5655.PubMedCrossRefGoogle Scholar
- Rosenbaum,, J. S., Zera, P., Umans, V. A., Ginsburg, R., and Hoffman, B. B. (1986) Desensitization of aortic smooth muscle contraction in rats harboring pheochromocytoma. J. Pharm. Exp. Ther. 238, 396–400.Google Scholar
- Ruffolo, R. R., Jr., and Kopia, G. A. (1986) Importance of receptor regulation in the pathophysiology and therapy of congestive heart failure. Am. J. Med., in press.Google Scholar
- Smith, J. M., Jones, S. B., Bylund, D. B., and Jones, A. W. (1986) Characterization of alpha-1 adrenergic receptors in the thoracic aorta of control and aldosterone hypertensive rats: Correlation of radioligand binding with potassium efflux and contraction. J. Pharmacol. Exp. Ther., in press.Google Scholar
- Studer, R. K., and Borle, A. B. (1982) Differences between male and female rats in the regulation of hepatic glycogenolysis. J. Physiol. Chem. 257, 7987–7993.Google Scholar
- Su, Y. F., Cubeddu, L., and Perkins, J. P. (1976) Regulation of adenosine 3’:5’-monophosphate content of human astrocytoma cells: Desensitization to catecholamines and prostaglandins. J. Cycl. Nucleotide Res. 2, 257–270.Google Scholar
- Wei, J. W., Ganis, R. A., Daniel, E. E. (1976) Isolation and characterization of plasma membrane from rat mesenteric arteries. Blood Vess. 13, 279–292.Google Scholar