Abstract
The effects of 5-hydroxytryptamine (5-HT, serotonin) on the central nervous system can be broadly divided according to its influence on cell excitability, and indeed, both excitatory and inhibitory effects of 5-HT have been frequently reported (see, for example, Roberts and Straughan, 1967). This description of 5-HT function is, however, an oversimplification, since it does not take into account either possible 5-HT receptor subtypes or different anatomical locations for the effects of this neurotransmitter.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andén, N. E., Dahlström, A., Fuxe, K., Larsson, K., Olson, L., and Ungerstedt, U. (1966) Ascending monoamine neurones to the telecephalon and diencephalon. Acta. Physiol. Scan. 67, 313–326.
Baumann, P. A. and Waldmeier, P. C. (1981) Further evidence for negative feedback control of serotonin release in the central nervous system. Naunyn Schmiedebergs Arch. Pharmacol. 317, 36–43.
Baumann, P. A. and Waldmeier, P. C. (1984) Negative feedback control of serotonin release in vivo: Comparison of 5-hydroxyindolacetic acid levels measured by voltammetry in conscious rats and by biochemical techniques. Neuroscience 11, 195–204.
Bonanno, G., Maura, G., and Raiteri, M. (1986) Pharmacological characterization of release regulating serotonin autoreceptors in rat cerebellum. Eur. J. Pharmacol. 126, 317–321.
Bourgoin, S., Artaud, F., Enjalbert, A., Héry, F., Glowinski, J., and Hamon M. J. (1977) Acute changes in central serotonin metabolism induced by blockade or stimulation of serotonergic receptors during ontogenesis in the rat.J. Pharmacol. Exp. Ther. 202, 519–531.
Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., and Saxena, P. R. (1986) Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacol. 25, 563–576.
Brazell, M. P., Marsden, C. A., Nisbet, A. P., and Routledge, C. (1985) The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br. J. Pharmacol. 86, 209–216.
Butler, S. (1984) Present status of tricyclic antidepressants in chronic pain therapy. Adv. Pain Res. Therap. 7, 173–196.
Cerrito, F. and Raiteri, M. (1979) Serotonin release is modulated by presynaptic autoreceptors. Eur. J. Pharmacol. 57, 427–430.
Ceulemans, D. L. S., Hoppenbrouwers, M.-L. J. A., Gelders, Y. G., Reynt-jens, A. J. M. (1985) The influence of ritanserin, a serotonin antagonist, in anxiety disorders: A double-blind placebo-controlled study versus lorazepam. Pharmacopsychiat. 18, 303–305.
Chaput, Y., Blier, P., and de Montigny, C. (1986) In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. J. Neurosci. 6, 2796–2801.
Chase, T. N., Breese, G. R., and Kopin, I. J. (1967) Serotonin release from brain slices by electrical stimulation: Regional differences and effect of LSD. Science 157, 1461–1463.
Chesselet, M.-F. (1984) Presynaptic regulation of neurotransmitter release in the brain: Facts and Hypothesis. Neuroscience 12, 347–375.
Cox, B. and Ennis, C. (1982) Characterization of 5-hydroxytryptaminergic autoreceptors in the rat hypothalamus. J. Pharm. Pharmacol. 34, 438–441.
Eison, A. S., Eison, M. S., Stanley, M., and Riblet, L. A. (1986) Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacol. Biochem. Behav. 24, 701–707.
Engel, G., Göthert, M., Hoyer, D., Schlicker, E., and Hillenbrand, K. (1986) Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch. Pharmacol. 332, 1–7.
Engel, G., Göthert, M., Müller-Schweinitzer, E., Schlicker, E., Sistonen, L., and Stadler, P. A. (1983) Evidence for common pharmacological properties of [3H]-5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn Schmiedebergs Arch. Pharmacol. 324, 116–126.
Ennis, C. and Cox, B. (1982) Pharmacological evidence for the existence of two distinct serotonin receptors in rat brain. Neuropharmacol. 21, 41–44.
Farnebo, L.-O. and Hamberger, B. (1971) Drug-induced changes in the release of 3H-monoamines from field stimulated rat brain slices. Acta Physiol. Scand. 371, 35–44.
Figueroa, H. R., Yürgens, P. D., Newton, D. K., and Hall, T. R. (1985) Evidence for negative feedback control of the release of [3H]serotonin from superfused mouse cerebellum slices induced by electrical field stimulation. Gen. Pharmacol. 16, 103–108.
Galzin, A. M., Moret, C., Verzier, B., and Langer, Z. S. (1985) Interaction between tricyclic and nontricyclic 5-hyobx)xytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus. J. Pharmacol. Exp. Ther. 235, 200–211.
Giarcovich, S. and Enero, M. A. (1984) Decreased brain serotonergic activity after acute propranolol. Eur. J. Pharmacol. 100, 123–125.
Göthert, M. (1980) Serotonin-receptor-mediated modulation of Ca2+-dependent 5-hydroxytryptamine release from neurones of the rat brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. 314, 223–230.
Göthert, M. (1982) Modulation of serotonin release in the brain via presynaptic receptors. Trends Pharmacol. Sci. 3, 437–440.
Göthert, M. and Schlicker, E. (1983) Autoreceptor-mediated inhibition of 3H-5-hydroxytryptamine release from rat brain cortex slices by analogues of 5-hydroxytryptamine. Life Sci. 32, 1183–1191.
Göthert, M. and Weinheimer, G. (1979) Extracellular 5-hydroxytryptamine inhibits 5-hydroxytryptamine release from rat brain cortex slices. Naunyn Schmiedebergs Arch. Pharmacol. 310, 93–96.
Gozlan, H., El Mestikawy, S., Pichat, L., Glowinski, J., and Hamon, M. (1983) Identification of presynaptic autoreceptors using a new ligand: 3H-PAT. Nature 305, 140–142.
Hall, M. D., El Mestikawy, S., Emerir, M. B., Pichat, L., Hamon, M., and Gozlan, H. (1985) [3H]8-Hydroxy-2-(di-n-propylamino) tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J. Neurochem. 44, 1685–1696.
Hammond, D. L. (1985) Pharmacology of central pain-modulating networks (biogenic amines and nonopiod analgesics). Adv. Pain Res. Therap. 9, 499–511.
Hamon, M., Bourgoin, S., Gozlan, H., Hall, M. D., Goetz, C., Artaud, F., and Horn, A. S. (1984) Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamono) tetralin) in the rat brain. Eur. J. Pharmacol. 100, 263–276.
Hamon, M., Bourgoin, S., Jagger, J. J., and Glowinski, J. (1974) Effects of LSD on synthesis and release of 5-HT in rat brain slices. Brain Res. 69, 265–280.
Héry, F., Simonnet, S., Bourgoin, S., Soubrié, P., Artaud, F., Hamon, M., and Glowinski, J. (1979) Effect of nerve activity on the in vivo release of [3H]serotonin continuously formed from L-[3H]tryptophan in the caudate nucleus of the cat. Brain Res. 169, 317–334.
Heuring, R. E., Schlegel, J. R., and Peroutka, S. J. (1986) Species variation in RU 24969 interactions with non-5-HT1A binding sites. Eur. J. Pharmacol. 122, 279–282.
Hibert, M. and Middlemiss, D. N. (1986) Steroselective blockade at the 5-HT autoreceptor and inhibition of radioligand binding sites by the optical isomers of methiothepin. Neuropharmacol. 25, 1–4.
Hjorth, S. and Carlsson, A. (1986) Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors? Eur. J. Pharmacol. 129, 131–138.
Hoyer, D., Pazos, A., Probst, A., and Palacios, J. M. (1986) Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain Res. 376, 85–96.
Hutson, P. H., Dourish, C. T., and Curzon, G. (1986) Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors. Eur. J. Pharmacol. 129, 347–352.
Iversen, S. D. (1984) 5-HT and anxiety. Neuropharmacol. 23, 1553–1560.
Jacoby, J. H., Schabshelowitz, H., Fernstrom, J. D., and Wurtman, R. J. (1975) The mechanisms by which methiothepin, a putative serotonin receptor antagonist, increases brain 5-hydroxyindole levels. J. Pharmacol Exp. Ther. 195, 257–264.
Jones, B. J., Oakley, N. R., and Tyers, M. B. (1987) The anxiolytic activity of GR 38032F, a 5-HT3 receptor antagonist, in the rat and cynomolgus monkey. Br. J. Pharmacol. 90, 88P.
Katz, R. I. and Kopin, I. J. (1969) Effect of d-LSD and related compounds on release of norepinephrine-H3 and serotonin-H3 evoked from brain slices by electrical stimulation. Pharmacol. Res. Commun. 1, 54–62.
Korpi, E. R. and Oja, S. S. (1984) Comparison of two superfusion systems for the study of neurotransmitter release from rat cerebral cortex slices. J. Neurochem. 43, 236–242.
Langer, S. F. and Moret, C. (1982) Citalopram antagonizes the stimulation by lysergic acid diethlamide of presynaptic inhibitory serotonin autoreceptors in the rat hypothalamus. J. Pharmacol. Exp. Ther. 222, 220–226.
Limberger, N., Bonanno, G., Spath, L., and Starke, K. (1986) Autoreceptors and α 2-adrenoceptors at the serotonergic axons of rabbit brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. 332, 324–331.
Maidment, N. T., Routledge, C., Martin, K. F., Brazell, M. P., and Marsden, C. A. (1986) Identification of neurotransmitter autoreceptors using measurement of release in vivo, in Monitoring Neurotransmitter Release during Behaviour (Joseph M. H., Fillenz M., MacDonald I. A., and Marsden C. A., eds.), pp. 73–93. Ellis Horwood, Chichester, UK.
Marsden, C. A. and Martin, K. F. (1985) In vivo voltammetric evidence that the 5-HT autoreceptor is not of the 5-HTia subtype. Br. J. Pharmacol. 86, 445P.
Marsden, C. A. and Martin, K. F. (1986) Involvement of 5-HT1A- and α 2-receptors in the decreased 5-hydroxytryptamine release and metabolism in rat suprachiasmatic nucleus after intravenous 8-hydroxy-2-(n-dipropylamino) tetralin. Br. J. Pharmacol. 89, 277–286.
Martin, K. F. and Marsden, C A. (1986) In vivo voltammetry in the suprachiasmatic nucleus of the rat: Effects of RU 24969, methiothepin and ketanserin. Eur. J. Pharmacol. 121, 135–139.
Martin, L. L. and Sanders-Bush, E. (1982a) Comparison of the pharmacological characteristics of 5HT1 and 5HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release. Naunyn Schmiedebergs Arch. Pharmacol. 321, 165–170.
Martin, L. L. and Sanders-Bush, E. (1982b) The serotonin autoreceptor: Antagonism by quipazine. Neuropharmacol. 21, 445–450.
Maura, G. and Raiteri, M. (1984) Functional evidence that chronic drugs induce adaptive changes of central autoreceptors regulating serotonin release. Eur. J. Pharmacol. 97, 309–313.
Maura, G., Roccatagliata, E., and Raiteri, M. (1986) Serotonin autoreceptor in rat hippocampus: Pharmacological characterization as a subtype of the 5-HT1 receptor. Naunyn Schmiedebergs Arch. Pharmacol. 334, 323–326.
Maura, G., Ulivi, M., and Raiteri, M. (1987) (-)-Propranolol and (±)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in hippocampus of the rat brain. Neuropharmacol. 26, 713–717.
Middlemiss, D. N. (1982) Multiple 5-hydroxytryptamine receptors, in Presynaptic Receptors: Mechanisms and Functions (de Belleroche, J., ed.), pp. 46–74. Ellis Horwood, Chichester, UK.
Middlemiss, D. N. (1984a) Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol. Eur. J. Pharmacol. 101, 289–293.
Middlemiss, D. N. (1984b) 8-Hydroxy-2-(di-n-propylamino)tetralin is devoid of activity at the 5-hydroxytryptamine receptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H]5-HT recognition site. Naunyn Schmiedebergs Arch. Pharmacol. 327, 18–22.
Middlemiss, D.N. (1985) The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J. Pharm. Pharmacol. 37, 434–437.
Middlemiss, D. N. (1986) Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists. Eur. J. Pharmacol. 120 51–56.
Middlemiss, D.N. (1987) Lack of effect of the putative 5-HT1A receptor agonist, 8-OH-DPAT, on 5-HT release in vitro, in Brain 5-HT 1A Receptors: Behavioural and Neurochemical Pharmacology (Dourish, C. T., Ahlenius, S., and Hutson, P. H., eds.), pp. 82–93, Ellis Horwood, Chichester, UK.
Middlemiss, D. N., Bowen, D. M., and Palmer, A. M. (1986) Serotonin neurones and receptors in Alzheimer’s Disease, in New Concepts in Alzheimer’s Disease (Briley M., Kato A. C., and Weber M., eds.), pp 89–102. Macmillan, London, U.K.
Middlemiss, D. N. and Bremer, M. E. (1987) The terminal 5-HT autoreceptor in the guinea-pig frontal cortex: A pharmacological analysis. Br. J. Pharmacol. 92, 599P.
Middlemiss, D. N. and Fozard, J. R. (1983) 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur. J. Pharmacol. 90, 151–153.
Middlemiss, D. N. and Spedding, M. (1985) A functional correlate for the dihydropyridine binding site in rat brain. Nature 314, 94–96.
Minnema, D. and Michaelson, I. A. (1985) A superfusion apparatus for the examination of neurotransmitter release from synaptosomes. J. Neuroscience Meth. 14, 193–206.
Mitchell, R. and Fleetwood-Walker, S. (1981) Substance P, but not TRH, modulates the 5-HT autoreceptor in ventral lumbar spinal cord. Eur. J. Pharmacol. 76, 119–120.
Monachon, M. A., Burckard, W. P., Jalfre, M., and Haefely, W. (1972) Blockade of central 5-hydroxytryptamine receptors by methiothepin. Naunyn Schmiedebergs Arch. Pharmacol. 274, 192–197.
Monroe, P. J., Michaux, K., and Smith, D. J. (1986) Evaluation of the direct actions of drugs with a serotonergic link in spinal analgesia on the release of [3H] serotonin from spinal cord synaptosomes. Neuropharmacol. 25, 261–265.
Monroe, P. J. and Smith, D. J. (1985) Demostration of an autoreceptor modulating the release of [3H]5-hydroxytryptamine from a synaptosomal-rich spinal cord tissue preparation. J. Neurochem. 45, 1886–1894.
Moret, C. (1985) Pharmacology of the serotonin autoreceptor, in Neuropharmacology of Serotonin (Green A. R., ed.), pp. 21–49. Oxford University, Oxford, UK.
Moret, C. and Briley, M. (1986) Dihydroergocristine-induced stimulation of the 5-HT autoreceptor in the hypothalamus of the rat. Neuropharmacol. 25, 169–174.
Mounsey, I., Brady, K. A., Carroll, J., Fisher, R., and Middlemiss, D. N. (1982) K+-evoked [3H]-5-HT release from rat frontal cortex slices: The effect of 5-HT agonists and antagonists. Biochem. Pharmacol. 31, 49–53.
Nieuwenhuys, R., Voogd, J., and van Huijzen, C. (1979) The Human Central Nervous System: A Synopsis and Atlas, Springer-Verlag, Berlin, FRG.
Nowycky, M. C., Fox, A. P., and Tsien, R. W. (1985) Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316, 440–443.
Offord, S. J. and Warwick, R. O. (1987) Differential effects of nialamide and clomipramine on serotonin efflux and autoreceptors. Pharmacol Biochem. Behavior 26, 593–600.
Palfreyman, M. G., Mir, A. K., Kubina, M., Middlemiss, D. N., Richards, M., Tricklebank, M. D., and Fozard, J. R. (1986) Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site directed inhibitor of monoamine oxidase. Eur. J. Pharmacol. 130, 73–89.
Passarelli, F., Galzin, A.-M., and Langer, S. Z. (1987) Interaction between neuronal uptake inhibitors and presynaptic serotonin autoreceptors in rat hypothalamic slices: Comparison of K+ and electrical depolarization. J. Pharmacol Exp. Ther. 242, 1056–1063.
Pelayo, F., Dubocovich, M. L., and Langer, S. Z. (1980) Inhibition of neuronal uptake reduces the presynaptic effects of Clonidine but not of α-methyl-noradrenaline on the stimulation-evoked release of [3H]-noradrenaline from rat occipital cortex slices. Eur. J. Pharmacol. 64, 143–155.
Peroutka, S. J. (1985) Selective interaction of novel anxiolytics with 5-hydroxy-tryptamineiA receptors. Biol Psych. 20, 971–979.
Pettibone, D. J. and Pflueger, A. B. (1984) Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo: Possible relation to serotonin autoreceptor function. J. Neuroehem. 43, 83–90.
Raiteri, M., Angelini, F., and Levi, G. (1974) A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur. J. Pharmacol. 25, 411–414.
Raiteri, M., Bonanno, G., Marchi, M., and Maura, G. (1984) Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors? J. Pharmacol. Exp. Ther. 231, 671–677.
Richards, M. H. (1985) Efflux of [3H]-5-hydroxytryptamine from rat hypothalamic slices by continuous electrical stimulation: Frequency-dependent responses to serotonergic antagonists and 5-hydroxytryptamine. Naunyn Schmiedebergs Arch. Pharmacol. 329, 359–366.
Richardson, B. P. and Engel, G. (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9, 424–428.
Roberts, M. H. T. and Straughan, D. W. (1967) Excitation and depression of cortical neurones by 5-hydroxytryptamine. J. Physiol. 193, 269–294.
Sanders-Bush, E. (1982) Regulation of serotonin storage and release, in Advances in Biochemical Psychopharmacology (Ho T., Schooler J. C., and Usdin E., eds.), pp 17–34. Raven, New York.
Sawada, M. and Nagatsu, T. (1986) Stimulation of the serotonin autoreceptor prevents the calcium-calmodulin dependent increase of serotonin biosynthesis in rat raphé slices. J. Neurochem. 46, 963–967.
Schlicker, E., Brandt, F., Classen, K., and Göthert, M. (1985a) Serotonin release in human cerebral cortex and its modulation via serotonin receptors. Brain Res. 331, 337–341.
Schlicker, E. and Göthert, M. (1981) Antagonistic properties of quipazine at presynaptic serotonin receptors and α-adrenoceptors in rat brain cortex slices. Naunyn Schmiedebergs Arch. Pharmacol. 317, 204–208.
Schlicker, E., Göthert, M., and Hillenbrand, K. (1985b) Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. 331, 398–401.
Schoemaker, H. and Langer, S. Z. (1986) [3H]8-OH-DPAT labels the serotonin transporter in the rat striatum. Eur. J. Pharmacol. 124, 371–373.
Schoffelmeer, A. N. M., Wardeh, G., and Mulder, A. H. (1985) Cyclic AMP facilitates the electrically evoked release of radiolabeled noradrenaline, dopamine and 5-hydroxytryptamine from rat brain slices. Naunyn Schmiedebergs Arch. Pharmacol. 330, 74–76.
Sprouse, J. S. and Aghajanian, G. K. (1986) (-)-Propranolol blocks the inhibition of serotonergic dorsal raphé cell firing by 5-HT1A selective agonists. Eur. J. Pharmacol. 128, 295–298.
Stauderman, K. A. and Jones, D. J. (1986) Presynaptic serotonin receptors regulate [3H]serotonin release from rat spinal cord synaptosomes. Eur. J. Pharmacol. 120, 107–109.
Suter, H. A. and Collard, K. J. (1983) The regulation of 5-hydroxytryptamine release from supervised synaptosomes by 5-hydroxytryptamine and its immediate precursors. Neurochem. Res. 8, 723–730.
Traber, J., Davies, M. A., Dompert, W. U., Glaser, T., Schuurman, T., and Seidel, P.-R. (1984) Brain serotonin receptors as a target for the putative anxiolytic TVXQ 7821. Brain Res. Bull. 12, 741–744.
Tricklebank, M. D., Middlemiss, D. N., and Fozard, J. R. (1984) 8-OH-DPAT: an enigmatic centrally active 5-HT agonist. Trends Pharmacol. Sci. 5, 415–416.
Verbeuren, T. J., Coen, E. P., Schoups, A., Van de Velde, R., Baeyens, R., and De Potter, W. P. (1984) Presynaptic serotonin receptors regulate the release of 3H-serotonin in hypothalamic slices of the rabbit. Naunyn Schmiedebergs Arch. Pharmacol. 327, 102–106.
Verge, D., Daval, G., Patey, A., Gozlan, H., El Mestikawy, S., and Hamon, M. (1985) Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur. J. Pharmacol. 113, 463–464.
Weissmann-Nanopoulus, D., Mach, E., Magre, J., Demassey, Y., and Pujol, J.-F. (1986) Evidence for the localization of 5HTia binding sites on serotonin containing neurons in the raphé dorsalis and raphé centralis nuclei of the rat brain. Neurochem. Int. 7, 1061–1072.
Yarbrough, G. G., Singh, D. K., and Pettibone, D. J. (1984) A comparative electrophysiological and biochemical assessment of serotonin (5-HT) and a novel 5-HT agonist (MK-212) on central serotonergic receptors. Neuropharmacol. 23, 1271–1277.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 The Humana Press Inc.
About this chapter
Cite this chapter
Middlemiss, D.N. (1988). Autoreceptors Regulating Serotonin Release. In: Sanders-Bush, E. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4560-5_7
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4560-5_7
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8912-8
Online ISBN: 978-1-4612-4560-5
eBook Packages: Springer Book Archive