Skip to main content

Autoreceptors Regulating Serotonin Release

  • Chapter
The Serotonin Receptors

Part of the book series: The Receptors ((REC))

Abstract

The effects of 5-hydroxytryptamine (5-HT, serotonin) on the central nervous system can be broadly divided according to its influence on cell excitability, and indeed, both excitatory and inhibitory effects of 5-HT have been frequently reported (see, for example, Roberts and Straughan, 1967). This description of 5-HT function is, however, an oversimplification, since it does not take into account either possible 5-HT receptor subtypes or different anatomical locations for the effects of this neurotransmitter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andén, N. E., Dahlström, A., Fuxe, K., Larsson, K., Olson, L., and Ungerstedt, U. (1966) Ascending monoamine neurones to the telecephalon and diencephalon. Acta. Physiol. Scan. 67, 313–326.

    Article  Google Scholar 

  • Baumann, P. A. and Waldmeier, P. C. (1981) Further evidence for negative feedback control of serotonin release in the central nervous system. Naunyn Schmiedebergs Arch. Pharmacol. 317, 36–43.

    Article  PubMed  CAS  Google Scholar 

  • Baumann, P. A. and Waldmeier, P. C. (1984) Negative feedback control of serotonin release in vivo: Comparison of 5-hydroxyindolacetic acid levels measured by voltammetry in conscious rats and by biochemical techniques. Neuroscience 11, 195–204.

    Article  PubMed  CAS  Google Scholar 

  • Bonanno, G., Maura, G., and Raiteri, M. (1986) Pharmacological characterization of release regulating serotonin autoreceptors in rat cerebellum. Eur. J. Pharmacol. 126, 317–321.

    Article  PubMed  CAS  Google Scholar 

  • Bourgoin, S., Artaud, F., Enjalbert, A., Héry, F., Glowinski, J., and Hamon M. J. (1977) Acute changes in central serotonin metabolism induced by blockade or stimulation of serotonergic receptors during ontogenesis in the rat.J. Pharmacol. Exp. Ther. 202, 519–531.

    PubMed  CAS  Google Scholar 

  • Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., and Saxena, P. R. (1986) Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacol. 25, 563–576.

    Article  CAS  Google Scholar 

  • Brazell, M. P., Marsden, C. A., Nisbet, A. P., and Routledge, C. (1985) The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br. J. Pharmacol. 86, 209–216.

    PubMed  CAS  Google Scholar 

  • Butler, S. (1984) Present status of tricyclic antidepressants in chronic pain therapy. Adv. Pain Res. Therap. 7, 173–196.

    Google Scholar 

  • Cerrito, F. and Raiteri, M. (1979) Serotonin release is modulated by presynaptic autoreceptors. Eur. J. Pharmacol. 57, 427–430.

    Article  PubMed  CAS  Google Scholar 

  • Ceulemans, D. L. S., Hoppenbrouwers, M.-L. J. A., Gelders, Y. G., Reynt-jens, A. J. M. (1985) The influence of ritanserin, a serotonin antagonist, in anxiety disorders: A double-blind placebo-controlled study versus lorazepam. Pharmacopsychiat. 18, 303–305.

    Article  CAS  Google Scholar 

  • Chaput, Y., Blier, P., and de Montigny, C. (1986) In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. J. Neurosci. 6, 2796–2801.

    PubMed  CAS  Google Scholar 

  • Chase, T. N., Breese, G. R., and Kopin, I. J. (1967) Serotonin release from brain slices by electrical stimulation: Regional differences and effect of LSD. Science 157, 1461–1463.

    Article  PubMed  CAS  Google Scholar 

  • Chesselet, M.-F. (1984) Presynaptic regulation of neurotransmitter release in the brain: Facts and Hypothesis. Neuroscience 12, 347–375.

    Article  PubMed  CAS  Google Scholar 

  • Cox, B. and Ennis, C. (1982) Characterization of 5-hydroxytryptaminergic autoreceptors in the rat hypothalamus. J. Pharm. Pharmacol. 34, 438–441.

    Article  PubMed  CAS  Google Scholar 

  • Eison, A. S., Eison, M. S., Stanley, M., and Riblet, L. A. (1986) Serotonergic mechanisms in the behavioral effects of buspirone and gepirone. Pharmacol. Biochem. Behav. 24, 701–707.

    Article  PubMed  CAS  Google Scholar 

  • Engel, G., Göthert, M., Hoyer, D., Schlicker, E., and Hillenbrand, K. (1986) Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedebergs Arch. Pharmacol. 332, 1–7.

    Article  PubMed  CAS  Google Scholar 

  • Engel, G., Göthert, M., Müller-Schweinitzer, E., Schlicker, E., Sistonen, L., and Stadler, P. A. (1983) Evidence for common pharmacological properties of [3H]-5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn Schmiedebergs Arch. Pharmacol. 324, 116–126.

    Article  PubMed  CAS  Google Scholar 

  • Ennis, C. and Cox, B. (1982) Pharmacological evidence for the existence of two distinct serotonin receptors in rat brain. Neuropharmacol. 21, 41–44.

    Article  CAS  Google Scholar 

  • Farnebo, L.-O. and Hamberger, B. (1971) Drug-induced changes in the release of 3H-monoamines from field stimulated rat brain slices. Acta Physiol. Scand. 371, 35–44.

    Article  CAS  Google Scholar 

  • Figueroa, H. R., Yürgens, P. D., Newton, D. K., and Hall, T. R. (1985) Evidence for negative feedback control of the release of [3H]serotonin from superfused mouse cerebellum slices induced by electrical field stimulation. Gen. Pharmacol. 16, 103–108.

    Article  PubMed  CAS  Google Scholar 

  • Galzin, A. M., Moret, C., Verzier, B., and Langer, Z. S. (1985) Interaction between tricyclic and nontricyclic 5-hyobx)xytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus. J. Pharmacol. Exp. Ther. 235, 200–211.

    PubMed  CAS  Google Scholar 

  • Giarcovich, S. and Enero, M. A. (1984) Decreased brain serotonergic activity after acute propranolol. Eur. J. Pharmacol. 100, 123–125.

    Article  PubMed  CAS  Google Scholar 

  • Göthert, M. (1980) Serotonin-receptor-mediated modulation of Ca2+-dependent 5-hydroxytryptamine release from neurones of the rat brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. 314, 223–230.

    Article  PubMed  Google Scholar 

  • Göthert, M. (1982) Modulation of serotonin release in the brain via presynaptic receptors. Trends Pharmacol. Sci. 3, 437–440.

    Article  Google Scholar 

  • Göthert, M. and Schlicker, E. (1983) Autoreceptor-mediated inhibition of 3H-5-hydroxytryptamine release from rat brain cortex slices by analogues of 5-hydroxytryptamine. Life Sci. 32, 1183–1191.

    Article  PubMed  Google Scholar 

  • Göthert, M. and Weinheimer, G. (1979) Extracellular 5-hydroxytryptamine inhibits 5-hydroxytryptamine release from rat brain cortex slices. Naunyn Schmiedebergs Arch. Pharmacol. 310, 93–96.

    Article  PubMed  Google Scholar 

  • Gozlan, H., El Mestikawy, S., Pichat, L., Glowinski, J., and Hamon, M. (1983) Identification of presynaptic autoreceptors using a new ligand: 3H-PAT. Nature 305, 140–142.

    Article  PubMed  CAS  Google Scholar 

  • Hall, M. D., El Mestikawy, S., Emerir, M. B., Pichat, L., Hamon, M., and Gozlan, H. (1985) [3H]8-Hydroxy-2-(di-n-propylamino) tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain. J. Neurochem. 44, 1685–1696.

    Article  PubMed  CAS  Google Scholar 

  • Hammond, D. L. (1985) Pharmacology of central pain-modulating networks (biogenic amines and nonopiod analgesics). Adv. Pain Res. Therap. 9, 499–511.

    CAS  Google Scholar 

  • Hamon, M., Bourgoin, S., Gozlan, H., Hall, M. D., Goetz, C., Artaud, F., and Horn, A. S. (1984) Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamono) tetralin) in the rat brain. Eur. J. Pharmacol. 100, 263–276.

    Article  PubMed  CAS  Google Scholar 

  • Hamon, M., Bourgoin, S., Jagger, J. J., and Glowinski, J. (1974) Effects of LSD on synthesis and release of 5-HT in rat brain slices. Brain Res. 69, 265–280.

    Article  PubMed  CAS  Google Scholar 

  • Héry, F., Simonnet, S., Bourgoin, S., Soubrié, P., Artaud, F., Hamon, M., and Glowinski, J. (1979) Effect of nerve activity on the in vivo release of [3H]serotonin continuously formed from L-[3H]tryptophan in the caudate nucleus of the cat. Brain Res. 169, 317–334.

    Article  PubMed  Google Scholar 

  • Heuring, R. E., Schlegel, J. R., and Peroutka, S. J. (1986) Species variation in RU 24969 interactions with non-5-HT1A binding sites. Eur. J. Pharmacol. 122, 279–282.

    Article  PubMed  CAS  Google Scholar 

  • Hibert, M. and Middlemiss, D. N. (1986) Steroselective blockade at the 5-HT autoreceptor and inhibition of radioligand binding sites by the optical isomers of methiothepin. Neuropharmacol. 25, 1–4.

    Article  CAS  Google Scholar 

  • Hjorth, S. and Carlsson, A. (1986) Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors? Eur. J. Pharmacol. 129, 131–138.

    Article  PubMed  CAS  Google Scholar 

  • Hoyer, D., Pazos, A., Probst, A., and Palacios, J. M. (1986) Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites. Brain Res. 376, 85–96.

    Article  PubMed  CAS  Google Scholar 

  • Hutson, P. H., Dourish, C. T., and Curzon, G. (1986) Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors. Eur. J. Pharmacol. 129, 347–352.

    Article  PubMed  CAS  Google Scholar 

  • Iversen, S. D. (1984) 5-HT and anxiety. Neuropharmacol. 23, 1553–1560.

    Article  CAS  Google Scholar 

  • Jacoby, J. H., Schabshelowitz, H., Fernstrom, J. D., and Wurtman, R. J. (1975) The mechanisms by which methiothepin, a putative serotonin receptor antagonist, increases brain 5-hydroxyindole levels. J. Pharmacol Exp. Ther. 195, 257–264.

    PubMed  CAS  Google Scholar 

  • Jones, B. J., Oakley, N. R., and Tyers, M. B. (1987) The anxiolytic activity of GR 38032F, a 5-HT3 receptor antagonist, in the rat and cynomolgus monkey. Br. J. Pharmacol. 90, 88P.

    Google Scholar 

  • Katz, R. I. and Kopin, I. J. (1969) Effect of d-LSD and related compounds on release of norepinephrine-H3 and serotonin-H3 evoked from brain slices by electrical stimulation. Pharmacol. Res. Commun. 1, 54–62.

    Article  CAS  Google Scholar 

  • Korpi, E. R. and Oja, S. S. (1984) Comparison of two superfusion systems for the study of neurotransmitter release from rat cerebral cortex slices. J. Neurochem. 43, 236–242.

    Article  PubMed  CAS  Google Scholar 

  • Langer, S. F. and Moret, C. (1982) Citalopram antagonizes the stimulation by lysergic acid diethlamide of presynaptic inhibitory serotonin autoreceptors in the rat hypothalamus. J. Pharmacol. Exp. Ther. 222, 220–226.

    PubMed  CAS  Google Scholar 

  • Limberger, N., Bonanno, G., Spath, L., and Starke, K. (1986) Autoreceptors and α 2-adrenoceptors at the serotonergic axons of rabbit brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. 332, 324–331.

    Article  PubMed  CAS  Google Scholar 

  • Maidment, N. T., Routledge, C., Martin, K. F., Brazell, M. P., and Marsden, C. A. (1986) Identification of neurotransmitter autoreceptors using measurement of release in vivo, in Monitoring Neurotransmitter Release during Behaviour (Joseph M. H., Fillenz M., MacDonald I. A., and Marsden C. A., eds.), pp. 73–93. Ellis Horwood, Chichester, UK.

    Google Scholar 

  • Marsden, C. A. and Martin, K. F. (1985) In vivo voltammetric evidence that the 5-HT autoreceptor is not of the 5-HTia subtype. Br. J. Pharmacol. 86, 445P.

    Google Scholar 

  • Marsden, C. A. and Martin, K. F. (1986) Involvement of 5-HT1A- and α 2-receptors in the decreased 5-hydroxytryptamine release and metabolism in rat suprachiasmatic nucleus after intravenous 8-hydroxy-2-(n-dipropylamino) tetralin. Br. J. Pharmacol. 89, 277–286.

    PubMed  CAS  Google Scholar 

  • Martin, K. F. and Marsden, C A. (1986) In vivo voltammetry in the suprachiasmatic nucleus of the rat: Effects of RU 24969, methiothepin and ketanserin. Eur. J. Pharmacol. 121, 135–139.

    Article  PubMed  CAS  Google Scholar 

  • Martin, L. L. and Sanders-Bush, E. (1982a) Comparison of the pharmacological characteristics of 5HT1 and 5HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release. Naunyn Schmiedebergs Arch. Pharmacol. 321, 165–170.

    Article  PubMed  CAS  Google Scholar 

  • Martin, L. L. and Sanders-Bush, E. (1982b) The serotonin autoreceptor: Antagonism by quipazine. Neuropharmacol. 21, 445–450.

    Article  CAS  Google Scholar 

  • Maura, G. and Raiteri, M. (1984) Functional evidence that chronic drugs induce adaptive changes of central autoreceptors regulating serotonin release. Eur. J. Pharmacol. 97, 309–313.

    Article  PubMed  CAS  Google Scholar 

  • Maura, G., Roccatagliata, E., and Raiteri, M. (1986) Serotonin autoreceptor in rat hippocampus: Pharmacological characterization as a subtype of the 5-HT1 receptor. Naunyn Schmiedebergs Arch. Pharmacol. 334, 323–326.

    Article  PubMed  CAS  Google Scholar 

  • Maura, G., Ulivi, M., and Raiteri, M. (1987) (-)-Propranolol and (±)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in hippocampus of the rat brain. Neuropharmacol. 26, 713–717.

    Article  CAS  Google Scholar 

  • Middlemiss, D. N. (1982) Multiple 5-hydroxytryptamine receptors, in Presynaptic Receptors: Mechanisms and Functions (de Belleroche, J., ed.), pp. 46–74. Ellis Horwood, Chichester, UK.

    Google Scholar 

  • Middlemiss, D. N. (1984a) Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol. Eur. J. Pharmacol. 101, 289–293.

    Article  PubMed  CAS  Google Scholar 

  • Middlemiss, D. N. (1984b) 8-Hydroxy-2-(di-n-propylamino)tetralin is devoid of activity at the 5-hydroxytryptamine receptor in rat brain. Implications for the proposed link between the autoreceptor and the [3H]5-HT recognition site. Naunyn Schmiedebergs Arch. Pharmacol. 327, 18–22.

    Google Scholar 

  • Middlemiss, D.N. (1985) The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J. Pharm. Pharmacol. 37, 434–437.

    Article  PubMed  CAS  Google Scholar 

  • Middlemiss, D. N. (1986) Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists. Eur. J. Pharmacol. 120 51–56.

    Article  PubMed  CAS  Google Scholar 

  • Middlemiss, D.N. (1987) Lack of effect of the putative 5-HT1A receptor agonist, 8-OH-DPAT, on 5-HT release in vitro, in Brain 5-HT 1A Receptors: Behavioural and Neurochemical Pharmacology (Dourish, C. T., Ahlenius, S., and Hutson, P. H., eds.), pp. 82–93, Ellis Horwood, Chichester, UK.

    Google Scholar 

  • Middlemiss, D. N., Bowen, D. M., and Palmer, A. M. (1986) Serotonin neurones and receptors in Alzheimer’s Disease, in New Concepts in Alzheimer’s Disease (Briley M., Kato A. C., and Weber M., eds.), pp 89–102. Macmillan, London, U.K.

    Google Scholar 

  • Middlemiss, D. N. and Bremer, M. E. (1987) The terminal 5-HT autoreceptor in the guinea-pig frontal cortex: A pharmacological analysis. Br. J. Pharmacol. 92, 599P.

    Google Scholar 

  • Middlemiss, D. N. and Fozard, J. R. (1983) 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur. J. Pharmacol. 90, 151–153.

    Article  PubMed  CAS  Google Scholar 

  • Middlemiss, D. N. and Spedding, M. (1985) A functional correlate for the dihydropyridine binding site in rat brain. Nature 314, 94–96.

    Article  PubMed  CAS  Google Scholar 

  • Minnema, D. and Michaelson, I. A. (1985) A superfusion apparatus for the examination of neurotransmitter release from synaptosomes. J. Neuroscience Meth. 14, 193–206.

    Article  CAS  Google Scholar 

  • Mitchell, R. and Fleetwood-Walker, S. (1981) Substance P, but not TRH, modulates the 5-HT autoreceptor in ventral lumbar spinal cord. Eur. J. Pharmacol. 76, 119–120.

    Article  PubMed  CAS  Google Scholar 

  • Monachon, M. A., Burckard, W. P., Jalfre, M., and Haefely, W. (1972) Blockade of central 5-hydroxytryptamine receptors by methiothepin. Naunyn Schmiedebergs Arch. Pharmacol. 274, 192–197.

    Article  PubMed  CAS  Google Scholar 

  • Monroe, P. J., Michaux, K., and Smith, D. J. (1986) Evaluation of the direct actions of drugs with a serotonergic link in spinal analgesia on the release of [3H] serotonin from spinal cord synaptosomes. Neuropharmacol. 25, 261–265.

    Article  CAS  Google Scholar 

  • Monroe, P. J. and Smith, D. J. (1985) Demostration of an autoreceptor modulating the release of [3H]5-hydroxytryptamine from a synaptosomal-rich spinal cord tissue preparation. J. Neurochem. 45, 1886–1894.

    Article  PubMed  CAS  Google Scholar 

  • Moret, C. (1985) Pharmacology of the serotonin autoreceptor, in Neuropharmacology of Serotonin (Green A. R., ed.), pp. 21–49. Oxford University, Oxford, UK.

    Google Scholar 

  • Moret, C. and Briley, M. (1986) Dihydroergocristine-induced stimulation of the 5-HT autoreceptor in the hypothalamus of the rat. Neuropharmacol. 25, 169–174.

    Article  CAS  Google Scholar 

  • Mounsey, I., Brady, K. A., Carroll, J., Fisher, R., and Middlemiss, D. N. (1982) K+-evoked [3H]-5-HT release from rat frontal cortex slices: The effect of 5-HT agonists and antagonists. Biochem. Pharmacol. 31, 49–53.

    Article  PubMed  CAS  Google Scholar 

  • Nieuwenhuys, R., Voogd, J., and van Huijzen, C. (1979) The Human Central Nervous System: A Synopsis and Atlas, Springer-Verlag, Berlin, FRG.

    Google Scholar 

  • Nowycky, M. C., Fox, A. P., and Tsien, R. W. (1985) Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316, 440–443.

    Article  PubMed  CAS  Google Scholar 

  • Offord, S. J. and Warwick, R. O. (1987) Differential effects of nialamide and clomipramine on serotonin efflux and autoreceptors. Pharmacol Biochem. Behavior 26, 593–600.

    Article  CAS  Google Scholar 

  • Palfreyman, M. G., Mir, A. K., Kubina, M., Middlemiss, D. N., Richards, M., Tricklebank, M. D., and Fozard, J. R. (1986) Monoamine receptor sensitivity changes following chronic administration of MDL 72394, a site directed inhibitor of monoamine oxidase. Eur. J. Pharmacol. 130, 73–89.

    Article  PubMed  CAS  Google Scholar 

  • Passarelli, F., Galzin, A.-M., and Langer, S. Z. (1987) Interaction between neuronal uptake inhibitors and presynaptic serotonin autoreceptors in rat hypothalamic slices: Comparison of K+ and electrical depolarization. J. Pharmacol Exp. Ther. 242, 1056–1063.

    PubMed  CAS  Google Scholar 

  • Pelayo, F., Dubocovich, M. L., and Langer, S. Z. (1980) Inhibition of neuronal uptake reduces the presynaptic effects of Clonidine but not of α-methyl-noradrenaline on the stimulation-evoked release of [3H]-noradrenaline from rat occipital cortex slices. Eur. J. Pharmacol. 64, 143–155.

    Article  PubMed  CAS  Google Scholar 

  • Peroutka, S. J. (1985) Selective interaction of novel anxiolytics with 5-hydroxy-tryptamineiA receptors. Biol Psych. 20, 971–979.

    Article  CAS  Google Scholar 

  • Pettibone, D. J. and Pflueger, A. B. (1984) Effects of methiothepin and lysergic acid diethylamide on serotonin release in vitro and serotonin synthesis in vivo: Possible relation to serotonin autoreceptor function. J. Neuroehem. 43, 83–90.

    Article  CAS  Google Scholar 

  • Raiteri, M., Angelini, F., and Levi, G. (1974) A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur. J. Pharmacol. 25, 411–414.

    Article  PubMed  CAS  Google Scholar 

  • Raiteri, M., Bonanno, G., Marchi, M., and Maura, G. (1984) Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors? J. Pharmacol. Exp. Ther. 231, 671–677.

    PubMed  CAS  Google Scholar 

  • Richards, M. H. (1985) Efflux of [3H]-5-hydroxytryptamine from rat hypothalamic slices by continuous electrical stimulation: Frequency-dependent responses to serotonergic antagonists and 5-hydroxytryptamine. Naunyn Schmiedebergs Arch. Pharmacol. 329, 359–366.

    Article  PubMed  CAS  Google Scholar 

  • Richardson, B. P. and Engel, G. (1986) The pharmacology and function of 5-HT3 receptors. Trends Neurosci. 9, 424–428.

    Article  CAS  Google Scholar 

  • Roberts, M. H. T. and Straughan, D. W. (1967) Excitation and depression of cortical neurones by 5-hydroxytryptamine. J. Physiol. 193, 269–294.

    PubMed  CAS  Google Scholar 

  • Sanders-Bush, E. (1982) Regulation of serotonin storage and release, in Advances in Biochemical Psychopharmacology (Ho T., Schooler J. C., and Usdin E., eds.), pp 17–34. Raven, New York.

    Google Scholar 

  • Sawada, M. and Nagatsu, T. (1986) Stimulation of the serotonin autoreceptor prevents the calcium-calmodulin dependent increase of serotonin biosynthesis in rat raphé slices. J. Neurochem. 46, 963–967.

    Article  PubMed  CAS  Google Scholar 

  • Schlicker, E., Brandt, F., Classen, K., and Göthert, M. (1985a) Serotonin release in human cerebral cortex and its modulation via serotonin receptors. Brain Res. 331, 337–341.

    Article  PubMed  CAS  Google Scholar 

  • Schlicker, E. and Göthert, M. (1981) Antagonistic properties of quipazine at presynaptic serotonin receptors and α-adrenoceptors in rat brain cortex slices. Naunyn Schmiedebergs Arch. Pharmacol. 317, 204–208.

    Article  PubMed  CAS  Google Scholar 

  • Schlicker, E., Göthert, M., and Hillenbrand, K. (1985b) Cyanopindolol is a highly potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Naunyn Schmiedebergs Arch. Pharmacol. 331, 398–401.

    Article  PubMed  CAS  Google Scholar 

  • Schoemaker, H. and Langer, S. Z. (1986) [3H]8-OH-DPAT labels the serotonin transporter in the rat striatum. Eur. J. Pharmacol. 124, 371–373.

    Article  PubMed  CAS  Google Scholar 

  • Schoffelmeer, A. N. M., Wardeh, G., and Mulder, A. H. (1985) Cyclic AMP facilitates the electrically evoked release of radiolabeled noradrenaline, dopamine and 5-hydroxytryptamine from rat brain slices. Naunyn Schmiedebergs Arch. Pharmacol. 330, 74–76.

    Article  PubMed  CAS  Google Scholar 

  • Sprouse, J. S. and Aghajanian, G. K. (1986) (-)-Propranolol blocks the inhibition of serotonergic dorsal raphé cell firing by 5-HT1A selective agonists. Eur. J. Pharmacol. 128, 295–298.

    Article  PubMed  CAS  Google Scholar 

  • Stauderman, K. A. and Jones, D. J. (1986) Presynaptic serotonin receptors regulate [3H]serotonin release from rat spinal cord synaptosomes. Eur. J. Pharmacol. 120, 107–109.

    Article  PubMed  CAS  Google Scholar 

  • Suter, H. A. and Collard, K. J. (1983) The regulation of 5-hydroxytryptamine release from supervised synaptosomes by 5-hydroxytryptamine and its immediate precursors. Neurochem. Res. 8, 723–730.

    Article  PubMed  CAS  Google Scholar 

  • Traber, J., Davies, M. A., Dompert, W. U., Glaser, T., Schuurman, T., and Seidel, P.-R. (1984) Brain serotonin receptors as a target for the putative anxiolytic TVXQ 7821. Brain Res. Bull. 12, 741–744.

    Article  PubMed  CAS  Google Scholar 

  • Tricklebank, M. D., Middlemiss, D. N., and Fozard, J. R. (1984) 8-OH-DPAT: an enigmatic centrally active 5-HT agonist. Trends Pharmacol. Sci. 5, 415–416.

    Article  CAS  Google Scholar 

  • Verbeuren, T. J., Coen, E. P., Schoups, A., Van de Velde, R., Baeyens, R., and De Potter, W. P. (1984) Presynaptic serotonin receptors regulate the release of 3H-serotonin in hypothalamic slices of the rabbit. Naunyn Schmiedebergs Arch. Pharmacol. 327, 102–106.

    Article  PubMed  CAS  Google Scholar 

  • Verge, D., Daval, G., Patey, A., Gozlan, H., El Mestikawy, S., and Hamon, M. (1985) Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur. J. Pharmacol. 113, 463–464.

    Article  PubMed  CAS  Google Scholar 

  • Weissmann-Nanopoulus, D., Mach, E., Magre, J., Demassey, Y., and Pujol, J.-F. (1986) Evidence for the localization of 5HTia binding sites on serotonin containing neurons in the raphé dorsalis and raphé centralis nuclei of the rat brain. Neurochem. Int. 7, 1061–1072.

    Article  Google Scholar 

  • Yarbrough, G. G., Singh, D. K., and Pettibone, D. J. (1984) A comparative electrophysiological and biochemical assessment of serotonin (5-HT) and a novel 5-HT agonist (MK-212) on central serotonergic receptors. Neuropharmacol. 23, 1271–1277.

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 The Humana Press Inc.

About this chapter

Cite this chapter

Middlemiss, D.N. (1988). Autoreceptors Regulating Serotonin Release. In: Sanders-Bush, E. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4560-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4560-5_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8912-8

  • Online ISBN: 978-1-4612-4560-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics