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5-HT Receptors Coupled to Phosphoinositide Hydrolysis

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Book cover The Serotonin Receptors

Part of the book series: The Receptors ((REC))

Abstract

More than a decade ago, Michell (1975) noted that receptors that mediate the release of calcium also activate inositol lipid turnover, and suggested that these two events might be related. Since then, enormous strides have been made in the elucidation of the biochemical mechanism and the physiological role of agonist-induced inositol lipid turnover. Many extensive reviews of this subject have appeared recently (e.g., Abdel-Latif, 1986; Berridge, 1986; Exton, 1986; Nahorski et al., 1986), and the current review will only briefly summarize the highlights of this signaling mechanism. The key reaction is the hydrolysis of plasma membrane phosphoinositides by a phosphodiesterase, phospholipase C, to yield second messengers (Fig. 1). Three phosphoinositides, phosphatidylinositol (PI), phosphatidylinositol-4-monophosphate (PIP), and phosphatidylinostiol-4,5-bisphosphate (PIP2), are degraded by phospholipase C to form diacylglycerol (DAG) and inositol phosphates. It is generally thought that the primary substrate for receptor-activated phospholipase C is PIP2, with hydrolysis yielding two second messengers, DAG and inositol-1,4,5-trisphosphate (IP3). Evidence exists that, in some systems, PI and PIP are also hydrolyzed by receptor-activated phospholipase C.

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Authors
  1. Elaine Sanders-Bush
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Editors and Affiliations

  1. Department of Pharmacology and Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Elaine Sanders-Bush

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© 1988 The Humana Press Inc.

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Sanders-Bush, E. (1988). 5-HT Receptors Coupled to Phosphoinositide Hydrolysis. In: Sanders-Bush, E. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4560-5_6

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  • DOI: https://doi.org/10.1007/978-1-4612-4560-5_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8912-8

  • Online ISBN: 978-1-4612-4560-5

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