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Mechanisms in Cancer Prevention by Dietary Antixodiants

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Nutrients and Cancer Prevention

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 23))

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Abstract

Epidemiological studies and data from experiments in vivo and in vitro support the notion that cancer is a multistep process in that a series of specific events is required to transform a normal cell into a malignant one (1,2).

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References

  1. C. Borek, The induction and control of radiogenic transformation in vitro: Cellular and molecular mechanisms, in: D. Grunberger and S. Goff (eds.), Mechanisms of Cellular Transformation by Carcinogenic Agents, Pergamon Press, New York, 1987, pp. 151–195.

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  2. C. Borek, Permissive and protective factors in malignant transformation of cells in culture, in: H. Greim et al. (eds.), The Biochemical Basis of Chemical Carcinogenesis, Raven Press, New York, 1984, pp. 175–188.

    Google Scholar 

  3. B.Z. Shilo and R.A. Weinberg, Unique transforming gene in carcinogen-transformed mouse cells, Nature, 289 (1981) 607–609.

    Article  CAS  Google Scholar 

  4. C. Borek, A. Ong, and H. Mason, Distinctive transforming genes in X-ray transformed mammalian cells, Proc. Natl. Acad. Sci. USA, 84 (1987) 794–798.

    Article  CAS  Google Scholar 

  5. C. Borek, D.L. Guernsey, A. Ong, and I.S. Edelman, Critical role played by thyroid hormone in induction of neoplastic transformation by chemical carcinogens in tissue culture, Proc. Natl. Acad. Sci. USA, 80 (1983) 5749–5752.

    Article  CAS  Google Scholar 

  6. C. Borek, Oncogenes, hormones and free radical processes in malignant transformation in vitro. Ann. N.Y. Acad. of Sci., 551 (1989) 95–102.

    Article  Google Scholar 

  7. C. Borek, The role of free radicals and antioxidants in cellular and molecular carcinogenesis in vitro, in: O. Hayaishi, E. Niki, M. Kondo, T. Yoshikawa (eds.), Medical, Biochemical and Chemical Aspects of Free Radicals, Elsevier Science Publishing Co., The Netherlands, 1461–1469.

    Google Scholar 

  8. C. Borek, A. Ong, H. Mason, L. Donahue, and J.E. Biaglow. Selenium and vitamin E inhibit radio-genic and chemically induced transformation in vitro via different mechanisms of action, Proc. Acad. Sci. USA, 83 (1986) 1490–1494.

    Article  CAS  Google Scholar 

  9. R. Doll and R. Peto, The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States, J. Natn. Cancer Inst., 66 (1981) 1191–1308.

    CAS  Google Scholar 

  10. C. Borek and W. Troll, Modifiers of free radicals inhibit in vitro the oncogenic actions of X-rays, bleomycin and the tumor promoter 12–0-tetradecanoylphorpbol 13-acetate, Proc. Natl. Acad. Sci. USA, 80 (1983) 1304–1307.

    Article  CAS  Google Scholar 

  11. C. Borek, Radiation and chemically induced transformation: Free radicals, antioxidants and cancer, Br. J. Cancer, 55 (1987) 74–76.

    CAS  Google Scholar 

  12. L. Packer, T.F. Slater, and R.L. Willson, Direct observation of a free radical interaction between vitamin E and vitamin C, Nature, 278 (1979) 737–738.

    Article  CAS  Google Scholar 

  13. E. Niki, T. Saito, A. Kawakami, and Y. Kamiya, Inhibition of oxidation of methyl linoleate in solùtion by vitamin E and vitamin C, J. Biol. Chem., 259 (1984) 4177–4182.

    CAS  Google Scholar 

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© 1990 The Humana Press Inc.

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Borek, C. (1990). Mechanisms in Cancer Prevention by Dietary Antixodiants. In: Prasad, K.N., Meyskens, F.L. (eds) Nutrients and Cancer Prevention. Experimental Biology and Medicine, vol 23. Humana Press. https://doi.org/10.1007/978-1-4612-4516-2_5

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  • DOI: https://doi.org/10.1007/978-1-4612-4516-2_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8856-5

  • Online ISBN: 978-1-4612-4516-2

  • eBook Packages: Springer Book Archive

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