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Effect of Nutrition on Carcinogenesis: Mechanisms Involving Nitrosamines

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Nutrients and Cancer Prevention

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 23))

Abstract

Dietary and nutritional factors are widely recognized to be important factors in the genesis of human cancer (1–4). The possible mechanisms involved have been discussed in several review articles (5–7). The high incidence of gastrointestinal cancers in many Third World countries is correlated with the presence of carcinogens, such as aflatoxin and nitrosamines, in the diet (8–10) as well as nutritional deficiencies which are believed to enhance carcinogenesis (7,11). For example, a higher risk for gastric cancer has been shown to be associated with infrequent consumption of fruits and vegetables (3,12–15). Similarly, a high incidence of esophageal cancer is frequently found among individuals who consume low levels of vegetables and fruits and with low plasma levels of vitamins C and E as well as other micronutrients. This chapter explores the possible mechanisms by which constituents in vegetables and fruits inhibit carcinogenesis by blocking the endogenous synthesis of carcinogenic N-nitroso compounds. The etiology of esophageal cancer in Linxian, China is discussed in detail to substantiate this possibility.

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Author information

Authors and Affiliations

  1. Department of Chemical Biology & Pharmacognosy, College of Pharmacy, Rutgers University, Piscataway, NJ, 08855-0789, USA

    Chung S. Yang

  2. Cancer Institute, Chinese Academy of Medical Sciences, Beijing, China

    Shih-Hsin Lu

Authors
  1. Chung S. Yang
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  2. Shih-Hsin Lu
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Editors and Affiliations

  1. Health Sciences Center, University of Colorado, 4200 East Ninth Avenue, 80262, Denver, CO, USA

    Kedar N. Prasad

  2. Irvine Medical Center, University of California, 101 The City Drive, Building 44, Route 81, 92668-3297, Orange, CA, USA

    Frank L. Meyskens Jr.

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© 1990 The Humana Press Inc.

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Yang, C.S., Lu, SH. (1990). Effect of Nutrition on Carcinogenesis: Mechanisms Involving Nitrosamines. In: Prasad, K.N., Meyskens, F.L. (eds) Nutrients and Cancer Prevention. Experimental Biology and Medicine, vol 23. Humana Press. https://doi.org/10.1007/978-1-4612-4516-2_4

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  • DOI: https://doi.org/10.1007/978-1-4612-4516-2_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8856-5

  • Online ISBN: 978-1-4612-4516-2

  • eBook Packages: Springer Book Archive

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