Retinoids and Prevention of Experimental Cancer

  • Richard C. Moon
Part of the Experimental Biology and Medicine book series (EBAM, volume 23)

Abstract

A dietary vitamin A deficiency results in clinical symptoms manifested by growth retardation, degeneration of reproductive organs, metaplasia and hyperkeratinization of epithelial tissues (1). Moreover, animals deficient in vitamin A are more susceptible to chemical carcinogens than are non-deficient animals (2,3). It has also been well documented that, the exogenous administration of retinoids to experimental animals suppress epithelial carcinogenesis in several organs (4,5). Similarly, in vitro studies have shown that the expression of malignant phenotype is also suppressed by certain retinoids (6).

Keywords

Selenium Tamoxifen Pyrene Prolactin Anthracene 

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References

  1. 1.
    Hicks, R.M. The scientific basis for regarding vitamin A and its analogues as anti-carcinogenic agents. Proc. Nutr. Soc., 42: 83–93, 1983.CrossRefGoogle Scholar
  2. 2.
    Rogers, A.E., Herndon, B.J., and Newberne, P.M. Induction by dimethylhydrazine of intestinal carcinoma in normal rats fed high and low levels of vitamin A. Cancer Res., 33: 1003–1009, 1973.Google Scholar
  3. 3.
    Cohen, S.M., Wittenberg, J.F., and Bryn, G.T. Effect of avitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2thiazolyl]formamide. Cancer Res., 36: 2334–2339, 1976.Google Scholar
  4. 4.
    Sporn, M.B., Dunlop, N.M., Newton, D.L., and Smith, J.M. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed. Proc., 35: 1335–1338, 1976.Google Scholar
  5. 5.
    Moon, R.C., McCormick, D.L., and Mehta, R.G. Inhibition of carcinogenesis by retinoids. Cancer Res., 43: 2469s - 2475s, 1983.Google Scholar
  6. 6.
    Lotan, R. Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochem. Biophys. Acta., 605: 33–91, 1980.Google Scholar
  7. 7.
    Moon, R.C., Grubbs, C.J., and Sporn, M.B. Inhibition of 7,12-dimethylbenz(a) anthracene-induced mammary carcinogenesis by retinyl acetate. Cancer Res., 36: 2626–2630, 1976.Google Scholar
  8. 8.
    McCormick, D.L., and Moon, R.C. Influence of delayed administration of retinyl acetate on mammary carcinogenesis. Cancer Res., 42: 2639–2643, 1982.Google Scholar
  9. 9.
    Moon, R.C., Thompson, H.J., Becci, P.J., Grubbs, C.J., Gander, R.J., Newton, D.L., Smith, J.M., Phillips, S.R., Henderson, W.R., Mullen, L.T., Brown, C.C., and Sporn, M.B. N-(4-hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat. Cancer Res., 39: 1339–1346, 1979.Google Scholar
  10. 10.
    McCormick, D.L., Sowell, Z.L., Thompson, C.A., and Moon, R.C. Inhibition by retinoid and ovariectomy of additional primary malignancies in rats following surgical removal of the first mammary cancer. Cancer, 51: 594–599, 1983.CrossRefGoogle Scholar
  11. 11.
    Maiorana, A., and Gullino, P. Effect of retinyl acetate on the incidence of mammary carcinomas and hepatomas in mice. J. Natl. Cancer Inst., 64: 655–663, 1980.Google Scholar
  12. 12.
    Welsch, C.W., Goodrich-Smith, M., Brown, C.C., and Crowe, N. Enhancement by retinyl acetate of hormone induced mammary tumorigenesis in female GR/A mice. J. Natl. Cancer Inst., 67: 935–938, 1981.Google Scholar
  13. 13.
    Welsch, C.W., DeHoog, J.V., and Moon, R.C. Inhibition of mammary tumorigenesis in nulliparous C3H mice by chronic feeding of the synthetic retinoid, N-(4hydroxyphenyl) retinamide. Carcinogenesis, 4: 1185–1187, 1983.CrossRefGoogle Scholar
  14. 14.
    Ratko, T.A., Detrisac, C.J., Dinger, N.M., Thomas, C.F., Kelloff, G.J., and Moon, R.C. Chemopreventive efficacy of combined retinoid and tamoxifen treatment following surgical excision of a primary mammary cancer in female rats. Cancer Res., 49: 4472–4476, 1989.Google Scholar
  15. 15.
    Welsch, C.W., Brown, C.K., Goodrich-Smith, M., Chiusano, J., and Moon, R.C. Synergistic effect of chronic prolactin suppression and retinoid treatment in the prophylaxis of N-methyl-N-nitrosourea-induced mammary tumorigenesis in female Sprague-Dawley rats. Cancer Res., 40: 3095–3098, 1980.Google Scholar
  16. 16.
    Bertram, J.S. Inhibition of neoplastic transformation in vitro by retinoids. Cancer Surveys, 3: 243–262, 1983.Google Scholar
  17. 17.
    Thompson, H.J., Meeker, L.D., and Becci, P.J. Effect of combined selenium and retinyl acetate treatment on mammary carcinogenesis. Cancer Res., 41: 1413–1416, 1981.Google Scholar
  18. 18.
    Ip, C., and Ip, M.M. Chemoprevention of mammary tumorigenesis by a combined regimen of selenium and vitamin A. Carcinogenesis, 2: 915–918, 1981.CrossRefGoogle Scholar
  19. 19.
    McCormick, D.L., Becci, P.J., and Moon, R.C. Inhibition of mammary and urinary bladder carcinogenesis by a retinoid and a maleic anhydridedivinyl ether copolymer (MVE-2). Carcinogenesis, 3: 1473–1477, 1982.CrossRefGoogle Scholar
  20. 20.
    Sporn, M.B., Squire, R.A., Brown, C.C., Smith, J.M., Wenk, M.L., and Springer, S. 13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat. Science, 195: 487–489, 1977.CrossRefGoogle Scholar
  21. 21.
    Moon, R.C., McCormick, D.L., Becci, P.J., Shealy, Y.F., Frickel, F., Paust, J., and Sporn, M.B. Influence of 15 retinoic acid amides on urinary bladder carcinogenesis in the mouse. Carcinogenesis, 3: 1469–1472, 1982.CrossRefGoogle Scholar
  22. 22.
    Becci, P.J., Thompson, H.J., Grubbs, C.J., Brown, C.C., and Moon, R.C. Effect of delay in administration of 13-cis-retinoic acid on the inhibition of urinary bladder carcinogenesis in the rat. Cancer Res., 39: 3141–3144, 1979.Google Scholar
  23. 23.
    Saffiotti, U., Montesano, R., Sellakumar, A.R., and Bork, S.A. Experimental cancer of the lung, inhibition by vitamin A of the induction of tracheobronchial metaplasia and squamous cell tumor. Cancer, 20: 857–864, 1967.CrossRefGoogle Scholar
  24. 24.
    Nettesheim, P., Cone, M.W., and Snyder, C. The influence of vitamin A on the susceptibility of the rat lung to 3-methylcholanthrene. Int. J. Cancer, 17: 341–357, 1976.CrossRefGoogle Scholar
  25. 25.
    Stinson, S.P., Reznik, G., and Donahoe, R. Effect of three retinoids on tracheal carcinogenesis with Nmethyl-N-nitrosourea in hamsters. J. Natl. Cancer Inst., 66: 947–951, 1981.Google Scholar
  26. 26.
    Grubbs, C.J., Becci, P.J., and Moon, R.C. Characterization of 1-methyl-l-nitrosourea (MNU)induced tracheal carcinogenesis and the effect of feeding the retinoid N-(4-hydroxyphenyl)retinamide (4-HPR). Proc. Am. Assoc. Cancer Res., 21: 102, 1980.Google Scholar
  27. 27.
    Mehta, R.G., Rao, K.V.N., Detrisac, C.J., Keiloff, G.J., and Moon, R.C. Inhibition of diethylnitrosamine-induced lung carcinogenesis by retinoids. Proc. Am. Assoc. Cancer Res., 29: 129, 1988.Google Scholar

Copyright information

© The Humana Press Inc. 1990

Authors and Affiliations

  • Richard C. Moon
    • 1
  1. 1.IIT Research InstituteChicagoUSA

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