Retinoids and Prevention of Experimental Cancer

  • Richard C. Moon
Part of the Experimental Biology and Medicine book series (EBAM, volume 23)


A dietary vitamin A deficiency results in clinical symptoms manifested by growth retardation, degeneration of reproductive organs, metaplasia and hyperkeratinization of epithelial tissues (1). Moreover, animals deficient in vitamin A are more susceptible to chemical carcinogens than are non-deficient animals (2,3). It has also been well documented that, the exogenous administration of retinoids to experimental animals suppress epithelial carcinogenesis in several organs (4,5). Similarly, in vitro studies have shown that the expression of malignant phenotype is also suppressed by certain retinoids (6).


Mammary Cancer Mammary Carcinogenesis Mammary Tumorigenesis Retinyl Palmitate Urinary Bladder Cancer 
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Copyright information

© The Humana Press Inc. 1990

Authors and Affiliations

  • Richard C. Moon
    • 1
  1. 1.IIT Research InstituteChicagoUSA

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