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Dietary Modulation of Tobacco-Specific Carcinogen Activation

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Nutrients and Cancer Prevention

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 23))

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Abstract

More than 85% of all lung cancer cases are associated to cigarette smoking (1). Among the 3800 different compounds present in cigarette smoke,50 of them have been identified as animal carcinogens (2). The N-nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-l-butanone (NNK) derived from nicotine during the curing and burning of tobacco is abundant in cigarette smoke (3). This N-nitrosamine has a remarkable organospecificity for lung tissues. Lung tumors are induced by this N-nitrosamine in rodents whether it is injected s. c., applied topically or by swabbing the oral mucosa (3). These results suggest that NNK could be a tobacco component involved in human pulmonary carcinogenesis. In chemoprevention studies, this N-nitrosamine provides not only an excellent model of lung carcinogenesis, but it is also a carcinogen ubiquitous in the human environment. Numerous epidemiological studies have concluded that vegetable consumption was associated with reduced lung cancer risk (4). The aim of our research program is to investigate how vegetables and fruits nutrients can inhibit pulmonary carcinogenesis induced by NNK in experimental animals.

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Author information

Authors and Affiliations

  1. Laboratory of Cancer Etiology and Chemoprevention, School of Pharmacy, Laval University, Quebec City, G1K 7P4, Canada

    A. Castonguay, P. Pepin, M. A. Alaoui-Jamali & G. Rossignol

Authors
  1. A. Castonguay
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  2. P. Pepin
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  3. M. A. Alaoui-Jamali
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  4. G. Rossignol
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Editor information

Editors and Affiliations

  1. Health Sciences Center, University of Colorado, 4200 East Ninth Avenue, 80262, Denver, CO, USA

    Kedar N. Prasad

  2. Irvine Medical Center, University of California, 101 The City Drive, Building 44, Route 81, 92668-3297, Orange, CA, USA

    Frank L. Meyskens Jr.

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© 1990 The Humana Press Inc.

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Castonguay, A., Pepin, P., Alaoui-Jamali, M.A., Rossignol, G. (1990). Dietary Modulation of Tobacco-Specific Carcinogen Activation. In: Prasad, K.N., Meyskens, F.L. (eds) Nutrients and Cancer Prevention. Experimental Biology and Medicine, vol 23. Humana Press. https://doi.org/10.1007/978-1-4612-4516-2_10

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  • DOI: https://doi.org/10.1007/978-1-4612-4516-2_10

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8856-5

  • Online ISBN: 978-1-4612-4516-2

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