Skip to main content
SpringerLink
Log in

Increases in Hepatic Gammaglutamyl Transferase Following Alcohol Consumption. A Hepatoprotective Rather Than a Pathogenic Role

  • Chapter
Molecular Mechanisms of Alcohol

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 21))

Abstract

Gamma-glutamyltransferase (GGT), the only enzyme known to initiate the degradative utilization of glutathione (gamma glutamyl-cysteinyl-glycine) is present in the plasma membrane of a number of cell types (14,23). Gammaglutamyltransferase catalyzes the hydrolytic cleavage of the gammaglutamyl linkage in glutathione to form glutamate and cysteinyl-glycine. The latter dipeptide is, in turn, hydrolyzed by dipeptidases to yield cysteine and glycine. In the presence of acceptors of the glutamate molecule, such as cysteine S-S-cysteine (cystine) present in the circulation, the GGT reaction can also yield gammaglutamyl-cystine. Both cysteine and gammaglutamyl-cystine can be re-utilized in the synthesis of glutathione (2,24,29).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, J.D., Lauterburg, B.H. and Mitchell, J.R. (1983) J. Pharmacol. Exp. Ther. 227, 749–754.

    PubMed  CAS  Google Scholar 

  2. Anderson, M. and Meister, A. (1983) Proc. Natl. Acad. Sci. (USA) 80, 707–711.

    Article  CAS  Google Scholar 

  3. Ballatori, N., Jacob, R. and Boyer, J.L. (1986) J. Biol. Chem. 261, 7860–7865.

    PubMed  CAS  Google Scholar 

  4. Boyland, E. and Chasseaud, L.F. (1970) Biochem. Pharmacol. 19, 1526–1528.

    Article  PubMed  CAS  Google Scholar 

  5. Gregus, Z., Steinm, A.F. and Klaasen, CD. (1987) Am. J. Physiol. 253, G86-G92.

    PubMed  CAS  Google Scholar 

  6. Griffith, O.W. and Meister, A. (1979) Proc. Natl. Acad. Sci (USA) 76, 268–272.

    Article  CAS  Google Scholar 

  7. Griffith, O.W. and Meister, A. (1979) Proc. Natl. Acad. Sci. (USA) 76, 5605–5610.

    Google Scholar 

  8. Griffith, O.W. and Meister, A. (1979) J. Biol. Chem. 254, 7558–7560.

    PubMed  CAS  Google Scholar 

  9. Griffith, O.W. and Meister, A. (1980) Proc. Natl. Acad. Sci (USA) 77, 3384–3387.

    Article  CAS  Google Scholar 

  10. Griffith, O.W. and Meister, A. (1986) Proc. Natl. Acad. Sci (USA) 83, 5029–5032.

    Article  Google Scholar 

  11. Gumucio, J.J. (1989) Hepatology 9, 154–160.

    Article  PubMed  CAS  Google Scholar 

  12. Harata, J., Nagata, M., Sasaki, E., Ishiguro, I., Ohta, Y. and Murakami Y. (1983) Biochem. Pharmacol. 32, 1795–1798.

    Article  PubMed  CAS  Google Scholar 

  13. Hetu, C, Yalle, L and Joly, J.C. (1982) Drug Metab. Disp. 10, 246–260.

    CAS  Google Scholar 

  14. Inoue, M. (1985) in: Renal Biochemistry (R. Kinne, ed.), Elsevier pp. 225–269.

    Google Scholar 

  15. Inoue, M., Kinne, R., Tran, T., Biempica, L. and Arias, I.M. (1983) J. Biol. Chem. 258, 5183–5188.

    PubMed  CAS  Google Scholar 

  16. Ishii, H., Ebihara, Y, Okuno, F., Munakata, Y., Takagi, T., Aral, M., Shigeta, S. and Tsuchiya, M. (1986) Alcoholism: Clin. Exp. Res. 10, 81–85.

    Article  CAS  Google Scholar 

  17. Ishii, H., Yasuraoka, S., Shigeta, Y, Takagi, S., Kamiya, T., Okuno, F. and Miyamoto, (1978) Life Sciences 23, 1393–1398.

    Article  PubMed  CAS  Google Scholar 

  18. Ivanov, E., Adjarov, D. and Etarska, T. (1980) Enzyme 25, 304–308.

    PubMed  CAS  Google Scholar 

  19. Lauterburg, B.H., Adams, J.D. and Mitchell, J.R. (1984) Hepatology 4, 586–590.

    Article  PubMed  CAS  Google Scholar 

  20. Lieber, CS. (1988) Seminars Liver Disease 8, 47–68.

    Article  CAS  Google Scholar 

  21. Lindros, K.O. and Penttila, K.E. (1985) Biochem. J. 228, 757–760.

    PubMed  CAS  Google Scholar 

  22. Meier, P., Szutl, E., Reuben, A. and Boyer, J. (1984) J. Cell. Biol. 98, 991–1000.

    Article  PubMed  CAS  Google Scholar 

  23. Meister, A. (1983) Ann. Rev. Biochem. 52, 711–760.

    Article  PubMed  CAS  Google Scholar 

  24. Orrenius, S., Ormstad, K., Thor, H. and Jewell, S.A. (1983) Fed. Proc. 42, 3177–3188.

    PubMed  CAS  Google Scholar 

  25. Pierson, J.L. and Mitchell, M.C. (1986) Biochemical Pharmacol. 35, 1533–1537.

    Article  CAS  Google Scholar 

  26. Seymoure, CA., Neale, G. and Peters, T.J. (1975) Gut 16, 839–840.

    Google Scholar 

  27. Speisky, H. (1986) Ph.D. Thesis, University of Toronto.

    Google Scholar 

  28. Speisky, H., Gunasekara, A., Varghese, G. and Israel, Y. (1987) Alcohol and Alcoholism, Suppl. 1, 245–250.

    Google Scholar 

  29. Speisky, H., Kera, Y., Penttila, K.E., Israel, Y. and Lindros, K. (1988) Alcoholism: Clin. Exp. Res. 12, 224–228.

    Article  CAS  Google Scholar 

  30. Speisky, H., Macdonald, A., Giles, G., Orrego, H. and Israel, Y. (1985) Biochem. J. 225, 565–572.

    PubMed  CAS  Google Scholar 

  31. Speisky, H., Schakll, N., Wade, D. and Israel, Y. (1989) submitted.

    Google Scholar 

  32. Williamson, J.M., Boettchen, B. and Meister, A. (1982) Proc. Natl. Acad. Sci. 79, 6246–6249.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pharmacology and Medicine, University of Toronto and Addiction Research Foundation, Toronto, Ontario, M5S 2S1, Canada

    Yedy Israel, Shigeyuki Nagata & Hernan Spiesky

Authors
  1. Yedy Israel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shigeyuki Nagata
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hernan Spiesky
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sinclair Research Farm, University of Missouri, Columbia, MO, USA

    Grace Y. Sun  & Albert Y. Sun  & 

  2. Department of Anatomy and Neurobiology, University of Missouri, Columbia, MO, USA

    P. Kevin Rudeen

  3. VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN, USA

    W. Gibson Wood

  4. Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, ROC

    Yau-Huei Wei

Rights and permissions

Reprints and permissions

Copyright information

© 1989 The Humana Press Inc.

About this chapter

Cite this chapter

Israel, Y., Nagata, S., Spiesky, H. (1989). Increases in Hepatic Gammaglutamyl Transferase Following Alcohol Consumption. A Hepatoprotective Rather Than a Pathogenic Role. In: Sun, G.Y., Rudeen, P.K., Wood, W.G., Wei, YH., Sun, A.Y. (eds) Molecular Mechanisms of Alcohol. Experimental Biology and Medicine, vol 21. Humana Press. https://doi.org/10.1007/978-1-4612-4514-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4514-8_21

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8855-8

  • Online ISBN: 978-1-4612-4514-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation