Skip to main content
SpringerLink
Log in

Effects of Acute and Chronic Ethanol Administration on Metabolism of Brain Acidic Phospholipids

  • Chapter
Molecular Mechanisms of Alcohol

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 21))

Abstract

Alcohol ingestion by man is known to produce well recognized effects on the central nervous system (CNS). While excessive drinking is associated with intoxication, chronic ethanol ingestion may result in the manifestations of tolerance and physical dependence. The central depressant effect of acute ethanol is associated with an inhibition of neuronal firing and suppression of neurotransmitter release. Ethanol can be regarded as an anesthetic compound (38); however, due to its high water solubility, the anesthetic potency of ethanol is very weak and a high concentration is required for nerve blocking activity. Although tolerance and physical dependence associated with chronic ethanol ingestion can be attributed largely to alterations of the neuronal membrane, the complex structural and functional organization of the brain has prevented biochemists to elucidate these events at the molecular level. In recent years, much effort has been devoted to examining the ethanol effects on various neurotransmitter systems (see review in reference 32), yet, these studies have not been able to arrive at a conclusion to discern whether or not ethanol acts preferentially on a particular neurotransmitter system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abdel-Latif,AA. (1986) Pharmacol Reviews 38, 227–272.

    CAS  Google Scholar 

  2. Abood, LG., Butler, M. and Reynolds, D. (1981) Mol. Pharmacol. 17, 290–294.

    Google Scholar 

  3. Armbrecht, HJ., Wood, W.g., Wise, R.W., Walsh, J.B., Thomas, B.N., Strong R. (1983) J. Pharmacol. Exp. Ther. 226, 387–391.

    PubMed  CAS  Google Scholar 

  4. Beauge, F., Stibler, H. and Borg, S.(1985) Alcoholism: Clinic. Exp. Res. 9, 322–326.

    Article  CAS  Google Scholar 

  5. Beauge, F. Fleuret, C, Barin, F. and Nordmann, R. (1984) Biochem. Pharmacol. 33, 3591–3595.

    Article  PubMed  CAS  Google Scholar 

  6. Berridge, M.J. (1984) Biochem. J. 220, 345–360.

    PubMed  CAS  Google Scholar 

  7. Chin, J.H., Goldstein, D.B. (1977) Science 196, 684–685.

    Article  PubMed  CAS  Google Scholar 

  8. Chin, J.H., Goldstein, D.B. (1977) Mol. Pharmacol. 13, 435–441.

    PubMed  CAS  Google Scholar 

  9. Chandrasekhar, R., Huang, H-M. and Sun, G.Y. (1988) J. Pharmacol. Exp. Ther. 245, 120–123.

    PubMed  CAS  Google Scholar 

  10. Chandrasekhar, R., Lin, T-N, and Sun, G.Y. (1988) Excerpta Medica, Intl. Congress Series 805, 295–298.

    Google Scholar 

  11. Chweh, A.Y. and Leslie, S.W. (1982) J. Neurochem. 38, 691–695.

    Article  PubMed  CAS  Google Scholar 

  12. Daniell, L.C., Brass, E.P. and Harris, RA. (1987) Mol. Pharmacol. 32, 831–837.

    PubMed  CAS  Google Scholar 

  13. Daniell, L.C. and Harris, RA. (1988) J. Pharmacol. Exp. Ther. 245, 1–7.

    PubMed  CAS  Google Scholar 

  14. Downes, C.P. (1986) Neurochem. Int. 9, 211–230.

    Article  PubMed  CAS  Google Scholar 

  15. Ellingson, J.S., Taraschi, T.F., Wu, A., Zimmerman, R. and Rubin, E. (1988) Proc. Natl. Acad. Sci. USA 85, 3353–3357.

    Article  PubMed  CAS  Google Scholar 

  16. Eichberg, J. and Hauser, G. (1967) Biochim. Biophys. Acta 146, 415–422.

    Google Scholar 

  17. Fisher, S.K. and Agranoff, B.W. (1987) J. Neurochem 48, 999–1017.

    Article  PubMed  CAS  Google Scholar 

  18. Floreani, M., Bonetti, A.C. and Carpenedo, F. (1981) Biochem. Biophys. Res. Commun. 101, 1337–1344.

    Article  PubMed  CAS  Google Scholar 

  19. Gonzales, R.A. and Crews, F.T. (1988) Alcoholism Clinic. Exp. Res. 12, 94–98.

    Article  CAS  Google Scholar 

  20. Gonzales, R.A., Theiss, C. and Crews, F.T. (1986) J. Pharma. Exp. Therapeutics 237, 92–98

    CAS  Google Scholar 

  21. Gonzales-Sastre, F., Eichberg, J. and Hauser, G. (1971) Biochim. Biophys. Acta 248, 96–104.

    Google Scholar 

  22. Gustavsson, L. (1987) Ph.D. Dissertation, Univ. Lund, Sweden.

    Google Scholar 

  23. Harris, R.A. and Schroeder, F. (1981) Mol. Pharmacol. 20, 128–137.

    PubMed  CAS  Google Scholar 

  24. Harris, R.A., Schmidt, J., Hitzemann, B.A. and Hitzemann, R.J. (1981) Science 212, 1290–1291.

    Article  PubMed  CAS  Google Scholar 

  25. Harris, R.A., Baxter, D.M., Mitchell, M.A. and Hitzemann, R.J. (1984) Mol. Pharmacol. 25, 401–409.

    PubMed  CAS  Google Scholar 

  26. Hitzemann, R.J., Schueler, H.E., Graham-Brittan, C, and Kreishman, G.P. (1986) Biochim. et Biophys. Acta 859, 189–197

    Article  CAS  Google Scholar 

  27. Hoffman, P.L., Moses, F. Luthin, G.R. and Tabakoff, B. (1986) Mol. Pharmacol. 30, 13–18.

    PubMed  CAS  Google Scholar 

  28. Huang, S.F-L and Sun, G.Y. (1986) Neurochem. Int. 9, 185–190.

    Article  PubMed  CAS  Google Scholar 

  29. Kimeiberg, H.K. and Papahadjopoulos, D. (1974) J. Biol. Chem. 249, 1071–1080.

    Google Scholar 

  30. Nishizuka, Y. (1986) Science 233, 305–312.

    Article  PubMed  CAS  Google Scholar 

  31. Ohsako, S. and Deguchi, T. (1981) J. Biol. Chem. 256, 10945–10948.

    PubMed  CAS  Google Scholar 

  32. Ollat, H., Parvez, H. and Parvez, S. (1988) Neurochem. Int. 13, 275–293.

    Article  PubMed  CAS  Google Scholar 

  33. Palatini, P. Dabbeni-Sala, F., Pitotti, A. and Mandersloot, J.C. (1977) Biochim. Biophys. Acta 466, 1–9.

    Article  PubMed  CAS  Google Scholar 

  34. Rottenberg, H., Waring, A., and Rubin, E., (1981) Science 213, 583–585.

    Article  PubMed  CAS  Google Scholar 

  35. Rubin, R., Thomas, AP. and Hoek, J.B. (1987) Arch. Biochem. Biophy. 256, 29–38.

    Article  CAS  Google Scholar 

  36. Saito, T., Lee, J.M., Hoffman P.L., and Tabadoff B., (1987) J. Neurochem. 48, 1817–1822.

    Article  PubMed  CAS  Google Scholar 

  37. Schroeder, F., Morrison, W.J., Gorka, C. and Wood, W.G. (1988) Biochim. et Biophys. Acta 946, 85–94.

    Article  CAS  Google Scholar 

  38. Seeman P. (1972) Pharmacol. Rev. 24, 583–655.

    PubMed  CAS  Google Scholar 

  39. Smith, T.L., Yamamura, HA. and Lee, L. (1986) Life Sci. 39, 1675–1684.

    Article  PubMed  CAS  Google Scholar 

  40. Stubbs, C.E., Williams, B.W., Pryor, C.L. and Rubin, E. (1988) Arch. Biochem. Biophy. 262(2), 560–573.

    Article  CAS  Google Scholar 

  41. Sun, A.Y. (1983) in: Neural Membranes (eds. Sun, G.Y., Bazan, N., Wu, J.Y., Porcellati, G. and Sun, A.Y.) The Humana Press Inc. Clifton, New Jersey, pp. 317–340.

    Google Scholar 

  42. Sun, A.Y. and Samorajski, T. (1970) J. Neurochem. 17, 1365–1372.

    Article  PubMed  CAS  Google Scholar 

  43. Sun, A.Y. and Samorajski, T. (1975) J. Neurochem. 24, 161–164.

    Article  PubMed  CAS  Google Scholar 

  44. Sun, A.Y. and Sun, G.Y. (1976) in: Functional and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems, (eds, Porcellati, Amaducci, and Galli) Plenum Publishing Corp. New York, pp. 169–197.

    Google Scholar 

  45. Sun, G.Y. (1988) in: Neuromethods: Lipids and related compounds, Vol. 7 (eds. A. Boulten, G. Baker and L.A. Horrocks) The Humana Press Inc. Clifton, New Jersey, pp.63–82.

    Google Scholar 

  46. Sun, G.Y, Huang, H-M., Chandrasekhar, R., Lee, D.I. and Sun, A.Y. (1987) J. Neurochem. 48, 974–980.

    Article  PubMed  CAS  Google Scholar 

  47. Sun, G.Y, Huang, H-M., Lee, D.I., Chung-Wang, Y-J., Wood, W.G., Strong, R. and Sun, A.Y. (1987) Alcohol and Alcoholism 22, 367–373.

    PubMed  CAS  Google Scholar 

  48. Sun, G.Y., Huang, H-M., Lee, D.Z. and Sun, AY. (1984) Life. Sci. 35, 2127–2133.

    Article  PubMed  CAS  Google Scholar 

  49. Sun, G.Y., Huang, H-M. and Sun, A.Y. (1986) in: Phospholipid Research and the Nervous System: Biochemical and Molecular Pharmacology (eds. L.A. Horrocks, L. Freysz and G. Toffano) Liviana Press, Padova, Italy, pp. 133–146.

    Google Scholar 

  50. Sun, G.Y., Huang, H-M. and Chandrasekhar, R. (1988b) Neurochem. Int. 13, 63–68.

    Article  PubMed  CAS  Google Scholar 

  51. Sun, G.Y. and Sun, AY. (1983) Biochem. Biophys. Res. Commun. 113, 262–268.

    Article  PubMed  CAS  Google Scholar 

  52. Sun, G.Y. and Sun, AY. (1985) Alcoholism: Clin. Exp. Res. 9, 164–180.

    Article  CAS  Google Scholar 

  53. Sun, G.Y. and Huang, S.F-L (1987) Neurochem. Int. 10, 361–369.

    Article  PubMed  CAS  Google Scholar 

  54. Sun, G.Y., Huang, H-M., Kelleher, J.A., Stubbs, E.B., Jr. and Sun, AY. (1988) Neurochem. Int. 12, 69–77.

    Article  PubMed  CAS  Google Scholar 

  55. Sun, G.Y. and Lin, T-N. (1989) Life. Sci. 44, 689–696.

    Article  PubMed  CAS  Google Scholar 

  56. Sun, G.Y., Tang, W., Lee, D.Z. and Sun, A.Y. (1983) Neurochem. Pathol. 1, 137–146.

    Article  CAS  Google Scholar 

  57. Tabakoff, B., Hoffman, P.L., Liljequist, S. (1987) Enzyme 37, 70–86.

    PubMed  CAS  Google Scholar 

  58. Tanaka, R. and Abood, L.G. (1964) Arch. Biochem. Biophys. 108, 47–52.

    Article  PubMed  CAS  Google Scholar 

  59. Taraschi, T.F., Wu, A. and Rubin, E. (1985) Biochemistry 24, 7096–7101.

    Article  PubMed  CAS  Google Scholar 

  60. Taraschi, T.F., Ellingson, J.S., Wu, A., Zimmerman, R. and Rubin, E. (1986) Proc. Natl. Acad. Sci. 83, 3669–3673.

    Article  PubMed  CAS  Google Scholar 

  61. Taraschi, T.F., Ellingson, J.S., Wu, A., Zimmerman R. and Rubin, E. (1986) Proc. Natl. Acad. Sci. 83, 9398–9402.

    Article  PubMed  CAS  Google Scholar 

  62. Wood, W.G. and Schroeder, F. (1988) Life Sciences 43, 467–475.

    Article  PubMed  CAS  Google Scholar 

  63. Wood, W.G., Gorka, C. and Schroeder, F. (1989) J. Neurochem. 53, 1925–1930.

    Article  Google Scholar 

  64. Yau, T.M. and Sun, G.Y. (1974) J. Neurochem. 23, 99–104.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sinclair Comparative Medicine Research Farm and Biochemistry Department, University of Missouri, Columbia, MO, 65203, USA

    Grace Y. Sun, Renuka Chandrasekhar & Hsueh-Meei Huang

Authors
  1. Grace Y. Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Renuka Chandrasekhar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hsueh-Meei Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sinclair Research Farm, University of Missouri, Columbia, MO, USA

    Grace Y. Sun  & Albert Y. Sun  & 

  2. Department of Anatomy and Neurobiology, University of Missouri, Columbia, MO, USA

    P. Kevin Rudeen

  3. VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN, USA

    W. Gibson Wood

  4. Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, ROC

    Yau-Huei Wei

Rights and permissions

Reprints and permissions

Copyright information

© 1989 The Humana Press Inc.

About this chapter

Cite this chapter

Sun, G.Y., Chandrasekhar, R., Huang, HM. (1989). Effects of Acute and Chronic Ethanol Administration on Metabolism of Brain Acidic Phospholipids. In: Sun, G.Y., Rudeen, P.K., Wood, W.G., Wei, YH., Sun, A.Y. (eds) Molecular Mechanisms of Alcohol. Experimental Biology and Medicine, vol 21. Humana Press. https://doi.org/10.1007/978-1-4612-4514-8_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4514-8_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8855-8

  • Online ISBN: 978-1-4612-4514-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation