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Prenatal Ethanol Studies on Astrocytes

  • Chapter
Molecular Mechanisms of Alcohol

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 21))

Abstract

Children born with fetal alcohol syndrome (FAS) or fetal alcohol effects (FAE) exhibit pre and postnatal growth deficiencies with specific damages to the central nervous system (CNS) (27, 43, 44). Clinical and experimental studies show microcephaly, mental retardation and specific biochemical and morphological alterations in cerebral tissue following perinatal alcohol exposure (11, 21, 23, 37, 38). Inhibition of [3H]-thymidine uptake/incorporation into DNA in fetal rat cells and tissues by ethanol (12), or inhibition of protein synthesis in fetal and neonatal brain by prenatal and postnatal alcohol exposure have been reported (47, 48). Significant deficits were observed in the dendritic structure of the hippocampus of 8 to 10 weeks-old adult offspring exposed in uteroto ethanol (2). Furthermore, alterations in hippocampal CAl pyramidal neurons in mice exposed perinatally to alcohol (9, 10) and high sensitivity of hippocampal messenger RNA (mRNA) among other available mRNA species to in utero ethanol exposure (51) have been demonstrated.

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Authors and Affiliations

  1. Department of Psychiatry and Human Behavior, California College of Medicine University of California, Irvine, Irvine, CA, 92717, USA

    Sujata Tewari, Thanh Hoang, David Winn, Kimberly Boyd & Hemalatha Parekh

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  1. Sujata Tewari
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  2. Thanh Hoang
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  3. David Winn
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  4. Kimberly Boyd
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  5. Hemalatha Parekh
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Editor information

Editors and Affiliations

  1. Sinclair Research Farm, University of Missouri, Columbia, MO, USA

    Grace Y. Sun  & Albert Y. Sun  & 

  2. Department of Anatomy and Neurobiology, University of Missouri, Columbia, MO, USA

    P. Kevin Rudeen

  3. VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN, USA

    W. Gibson Wood

  4. Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, ROC

    Yau-Huei Wei

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© 1989 The Humana Press Inc.

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Tewari, S., Hoang, T., Winn, D., Boyd, K., Parekh, H. (1989). Prenatal Ethanol Studies on Astrocytes. In: Sun, G.Y., Rudeen, P.K., Wood, W.G., Wei, YH., Sun, A.Y. (eds) Molecular Mechanisms of Alcohol. Experimental Biology and Medicine, vol 21. Humana Press. https://doi.org/10.1007/978-1-4612-4514-8_13

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  • DOI: https://doi.org/10.1007/978-1-4612-4514-8_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8855-8

  • Online ISBN: 978-1-4612-4514-8

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