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Prenatal Ethanol Studies on Astrocytes

  • Sujata Tewari
  • Thanh Hoang
  • David Winn
  • Kimberly Boyd
  • Hemalatha Parekh
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 21)

Abstract

Children born with fetal alcohol syndrome (FAS) or fetal alcohol effects (FAE) exhibit pre and postnatal growth deficiencies with specific damages to the central nervous system (CNS) (27, 43, 44). Clinical and experimental studies show microcephaly, mental retardation and specific biochemical and morphological alterations in cerebral tissue following perinatal alcohol exposure (11, 21, 23, 37, 38). Inhibition of [3H]-thymidine uptake/incorporation into DNA in fetal rat cells and tissues by ethanol (12), or inhibition of protein synthesis in fetal and neonatal brain by prenatal and postnatal alcohol exposure have been reported (47, 48). Significant deficits were observed in the dendritic structure of the hippocampus of 8 to 10 weeks-old adult offspring exposed in uteroto ethanol (2). Furthermore, alterations in hippocampal CAl pyramidal neurons in mice exposed perinatally to alcohol (9, 10) and high sensitivity of hippocampal messenger RNA (mRNA) among other available mRNA species to in utero ethanol exposure (51) have been demonstrated.

Keywords

Glial Fibrillary Acidic Protein Ethanol Exposure Brain Extract Fetal Alcohol Syndrome Glutamine Synthetase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1989

Authors and Affiliations

  • Sujata Tewari
    • 1
  • Thanh Hoang
    • 1
  • David Winn
    • 1
  • Kimberly Boyd
    • 1
  • Hemalatha Parekh
    • 1
  1. 1.Department of Psychiatry and Human BehaviorCalifornia College of Medicine University of California, IrvineIrvineUSA

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