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Mechanisms of Central Nervous System Alcohol-Related Birth Defects

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Molecular Mechanisms of Alcohol

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 21))

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Abstract

It has been widely demonstrated that ethanol consumption by pregnant women has adverse effects on the unborn child (13, 15, 40, 86). The complex of alcohol-induced abnormalities are known collectively as the fetal alcohol syndrome (FAS; 39). Physical malformations include craniofacial dysmorphology and growth retardation (12), whereas dysfunctions of the central nervous system (CNS) are manifest as mental retardation, poor coordination and hyperactive behavior. A substantial number of experimental studies have been performed to determine the features and the mechanism (s) of ethanol effects on the development of the CNS. Although there is no clear delineation of a single etiology for the effects of ethanol on the development of the CNS, there are now several lines of evidence which indicate that malformations of the developing CNS are the result of the interaction of ethanol with several systems. These presumptive “mechanisms”, whether related or unrelated to one another, certainly contribute to the overall effects of ethanol on the induction of CNS malformations during development.

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Authors and Affiliations

  1. Department of Anatomy & Neurobiology, The University of Missouri — Columbia School of Medicine, Columbia, Missouri, 65212, USA

    P. Kevin Rudeen & Julia A. Creighton

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  1. P. Kevin Rudeen
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  2. Julia A. Creighton
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Editors and Affiliations

  1. Sinclair Research Farm, University of Missouri, Columbia, MO, USA

    Grace Y. Sun  & Albert Y. Sun  & 

  2. Department of Anatomy and Neurobiology, University of Missouri, Columbia, MO, USA

    P. Kevin Rudeen

  3. VA Medical Center and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, MN, USA

    W. Gibson Wood

  4. Department of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, ROC

    Yau-Huei Wei

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Rudeen, P.K., Creighton, J.A. (1989). Mechanisms of Central Nervous System Alcohol-Related Birth Defects. In: Sun, G.Y., Rudeen, P.K., Wood, W.G., Wei, YH., Sun, A.Y. (eds) Molecular Mechanisms of Alcohol. Experimental Biology and Medicine, vol 21. Humana Press. https://doi.org/10.1007/978-1-4612-4514-8_12

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  • DOI: https://doi.org/10.1007/978-1-4612-4514-8_12

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