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Insect Neurochemistry and Neurophysiology · 1989 · pp 63–103Cite as

Insect Neurodevelopment: Gene Cascades in Drosophila

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Part of the book series: Experimental and Clinical Neuroscience ((ECN))

Abstract

How is an ectodermal cell specified to become a neural precursor? How do its progeny acquire their correct cellular identities? These questions are of central importance in neural development. Many genes have been identified which act at particular stages in a cascade of events during neurogenesis. A network of genes are involved in determining the number of neural precursors. Other genes have been found to act at the level of specifying cellular identities. One of these, cut, is required to specify the correct identity of a particular class of sensory organs. Another gene, numb, is needed for the progeny of sensory precursors to develop as neurons.

The nature of the products encoded by these genes suggests molecular mechanisms by which these genes exert their function. Some are DNA binding and may regulate transcription of other genes, while others are membrane proteins suggesting a function in cell-cell communication. Understanding the interactions of such genes will elucidate the mechanisms of neural development.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, UCSF, Box 0724, San Francisco, CA, 94143, USA

    Rolf Bodmer

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  1. Rolf Bodmer
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Editors and Affiliations

  1. Insect Reproduction Laboratory, USDA-ARS, Building 306, Room 323, BARC-East, 20705, Beltsville, Maryland, USA

    A. B. Borkovec  & Edward. P. Masler  & 

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Bodmer, R. (1990). Insect Neurodevelopment: Gene Cascades in Drosophila. In: Borkovec, A.B., Masler, E.P. (eds) Insect Neurochemistry and Neurophysiology · 1989 ·. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4512-4_3

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  • DOI: https://doi.org/10.1007/978-1-4612-4512-4_3

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8854-1

  • Online ISBN: 978-1-4612-4512-4

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