The Post-Infectious Chronic Fatigue Syndrome: Cell Surface Expression of LFA-1 And ICAM-1

Abstract

Cell adhesion between T lymphocytes and other cells, including macrophages, is an essential early event in generating effective immune response. In addition, cell adhesion molecules appear to play an important role in migration, homing and recirculation of lymphocytes. Recently, a number of cell adhesion molecules that enhance T lymphocyte functions have been defined and termed as lymphocyte function-associated or LFA antigens (1, 2). LFA-1, CD2, CD4, and CD8 antigens appear to function as adhesion molecules for T cell responses. More recently, ligands for a number of adhesion molecules have been defined (2, 3). These include intercellular adhesion molecule 1 (ICAM-1), a ligand for LFA-1, major histocompatibility complex (MHC) class I and class II antigen ligands for CD8 and CD4, respectively, and LFA-3, a ligand for CD2.